This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1xy1

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:52, 12 July 2023) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1xy1.jpg|left|200px]]
 
-
{{Structure
+
==CRYSTAL STRUCTURE ANALYSIS OF DEAMINO-OXYTOCIN. CONFORMATIONAL FLEXIBILITY AND RECEPTOR BINDING==
-
|PDB= 1xy1 |SIZE=350|CAPTION= <scene name='initialview01'>1xy1</scene>, resolution 1.04&Aring;
+
<StructureSection load='1xy1' size='340' side='right'caption='[[1xy1]], [[Resolution|resolution]] 1.04&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=NH2:AMINO GROUP'>NH2</scene>
+
<table><tr><td colspan='2'>[[1xy1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XY1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XY1 FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.04&#8491;</td></tr>
-
|GENE=
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPT:BETA-MERCAPTOPROPIONIC+ACID'>MPT</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-
}}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xy1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xy1 OCA], [https://pdbe.org/1xy1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xy1 RCSB], [https://www.ebi.ac.uk/pdbsum/1xy1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xy1 ProSAT]</span></td></tr>
-
 
+
</table>
-
'''CRYSTAL STRUCTURE ANALYSIS OF DEAMINO-OXYTOCIN. CONFORMATIONAL FLEXIBILITY AND RECEPTOR BINDING'''
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/NEU1_BOVIN NEU1_BOVIN] Neurophysin 1 specifically binds oxytocin. Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland.
-
 
+
<div style="background-color:#fffaf0;">
-
==Overview==
+
== Publication Abstract from PubMed ==
Two crystal structures of deamino-oxytocin have been determined at better than 1.1A resolution from isomorphous replacement and anomalous scattering x-ray measurements. In each of two crystal forms there are two closely related conformers with disulfide bridges of different chirality, which may be important in receptor recognition and activation.
Two crystal structures of deamino-oxytocin have been determined at better than 1.1A resolution from isomorphous replacement and anomalous scattering x-ray measurements. In each of two crystal forms there are two closely related conformers with disulfide bridges of different chirality, which may be important in receptor recognition and activation.
-
==About this Structure==
+
Crystal structure analysis of deamino-oxytocin: conformational flexibility and receptor binding.,Wood SP, Tickle IJ, Treharne AM, Pitts JE, Mascarenhas Y, Li JY, Husain J, Cooper S, Blundell TL, Hruby VJ, et al. Science. 1986 May 2;232(4750):633-6. PMID:3008332<ref>PMID:3008332</ref>
-
1XY1 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XY1 OCA].
+
-
 
+
-
==Reference==
+
-
Crystal structure analysis of deamino-oxytocin: conformational flexibility and receptor binding., Wood SP, Tickle IJ, Treharne AM, Pitts JE, Mascarenhas Y, Li JY, Husain J, Cooper S, Blundell TL, Hruby VJ, et al., Science. 1986 May 2;232(4750):633-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/3008332 3008332]
+
-
[[Category: Protein complex]]
+
-
[[Category: Blundell, T L.]]
+
-
[[Category: Cooper, S.]]
+
-
[[Category: Husain, J.]]
+
-
[[Category: Pitts, J E.]]
+
-
[[Category: Tickle, I J.]]
+
-
[[Category: Wood, S P.]]
+
-
[[Category: NH2]]
+
-
[[Category: hormone]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:16:01 2008''
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 1xy1" style="background-color:#fffaf0;"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
 +
[[Category: Blundell TL]]
 +
[[Category: Cooper S]]
 +
[[Category: Husain J]]
 +
[[Category: Pitts JE]]
 +
[[Category: Tickle IJ]]
 +
[[Category: Wood SP]]

Current revision

CRYSTAL STRUCTURE ANALYSIS OF DEAMINO-OXYTOCIN. CONFORMATIONAL FLEXIBILITY AND RECEPTOR BINDING

PDB ID 1xy1

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1xy1"
Personal tools