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4hjj

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==Structure Reveals Function of the Dual Variable Domain Immunoglobulin (DVD-Ig) Molecule==
==Structure Reveals Function of the Dual Variable Domain Immunoglobulin (DVD-Ig) Molecule==
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<StructureSection load='4hjj' size='340' side='right' caption='[[4hjj]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='4hjj' size='340' side='right'caption='[[4hjj]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4hjj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HJJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HJJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4hjj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HJJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HJJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vxv|2vxv]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hjj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hjj OCA], [https://pdbe.org/4hjj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hjj RCSB], [https://www.ebi.ac.uk/pdbsum/4hjj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hjj ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IL18, IGIF, IL1F4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hjj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hjj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hjj RCSB], [http://www.ebi.ac.uk/pdbsum/4hjj PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IL18_HUMAN IL18_HUMAN]] Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.
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[https://www.uniprot.org/uniprot/IL18_HUMAN IL18_HUMAN] Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4hjj" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Interleukin|Interleukin]]
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*[[Interleukin 3D structures|Interleukin 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: DiGiammarino, E]]
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[[Category: Large Structures]]
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[[Category: Edalji, R]]
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[[Category: DiGiammarino E]]
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[[Category: Ghayur, T]]
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[[Category: Edalji R]]
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[[Category: Gu, J]]
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[[Category: Ghayur T]]
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[[Category: Jakob, C G]]
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[[Category: Gu J]]
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[[Category: Judge, R A]]
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[[Category: Jakob CG]]
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[[Category: Li, Y]]
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[[Category: Judge RA]]
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[[Category: Dfab complex]]
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[[Category: Li Y]]
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[[Category: Dual variable domain immunoglobulin]]
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[[Category: Il-18]]
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[[Category: Immune system]]
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Current revision

Structure Reveals Function of the Dual Variable Domain Immunoglobulin (DVD-Ig) Molecule

PDB ID 4hjj

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