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1y6e

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[[Image:1y6e.gif|left|200px]]
 
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{{Structure
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==Orthorhombic glutathione S-transferase of Schistosoma japonicum==
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|PDB= 1y6e |SIZE=350|CAPTION= <scene name='initialview01'>1y6e</scene>, resolution 3.0&Aring;
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<StructureSection load='1y6e' size='340' side='right'caption='[[1y6e]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1y6e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_japonicum Schistosoma japonicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y6E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y6E FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y6e OCA], [https://pdbe.org/1y6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y6e RCSB], [https://www.ebi.ac.uk/pdbsum/1y6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y6e ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GST26_SCHJA GST26_SCHJA] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y6/1y6e_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y6e ConSurf].
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<div style="clear:both"></div>
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'''Orthorhombic glutathione S-transferase of Schistosoma japonicum'''
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==See Also==
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*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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The crystal structure of the 26 kDa glutathione S-transferase from Schistosoma japonicum (SjGST) was determined at 3 A resolution in the new space group P2(1)2(1)2(1). The structure of orthorhombic SjGST reveals unique features of the ligand-binding site and dimer interface when compared with previously reported structures. SjGST is recognized as the major detoxification enzyme of S. japonicum, a pathogenic helminth causing schistosomiasis. As resistance against the established inhibitor of SjGST, praziquantel, has been reported these results might prove to be valuable for the development of novel drugs.
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[[Category: Large Structures]]
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==About this Structure==
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1Y6E is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Schistosoma_japonicum Schistosoma japonicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y6E OCA].
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==Reference==
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X-ray structure of glutathione S-transferase from Schistosoma japonicum in a new crystal form reveals flexibility of the substrate-binding site., Rufer AC, Thiebach L, Baer K, Klein HW, Hennig M, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Mar 1;61(Pt, 3):263-5. Epub 2005 Feb 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16511012 16511012]
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[[Category: Glutathione transferase]]
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[[Category: Schistosoma japonicum]]
[[Category: Schistosoma japonicum]]
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[[Category: Single protein]]
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[[Category: Baer K]]
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[[Category: Baer, K.]]
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[[Category: Hennig M]]
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[[Category: Hennig, M.]]
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[[Category: Klein HW]]
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[[Category: Klein, H W.]]
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[[Category: Rufer AC]]
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[[Category: Rufer, A C.]]
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[[Category: Thiebach L]]
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[[Category: Thiebach, L.]]
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[[Category: dimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:18:56 2008''
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Current revision

Orthorhombic glutathione S-transferase of Schistosoma japonicum

PDB ID 1y6e

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