4rml

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:31, 9 October 2024) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 4rml is ON HOLD until Paper Publication
+
==Crystal structure of the Olfactomedin domain of latrophilin 3 in C2221 crystal form==
 +
<StructureSection load='4rml' size='340' side='right'caption='[[4rml]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[4rml]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RML FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.601&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rml OCA], [https://pdbe.org/4rml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rml RCSB], [https://www.ebi.ac.uk/pdbsum/4rml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rml ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/AGRL3_MOUSE AGRL3_MOUSE] Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells (PubMed:22405201, PubMed:25728924, PubMed:26235031). Plays a role in the development of glutamatergic synapses in the cortex (PubMed:22405201, PubMed:24739570). Important in determining the connectivity rates between the principal neurons in the cortex (PubMed:24739570).<ref>PMID:22405201</ref> <ref>PMID:24739570</ref> <ref>PMID:25728924</ref> <ref>PMID:26235031</ref>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Latrophilins (LPHNs) are adhesion-like G-protein-coupled receptors implicated in attention-deficit/hyperactivity disorder. Recently, LPHN3 was found to regulate excitatory synapse number through trans interactions with fibronectin leucine-rich repeat transmembrane 3 (FLRT3). By isothermal titration calorimetry, we determined that only the olfactomedin (OLF) domain of LPHN3 is necessary for FLRT3 association. By multi-crystal native single-wavelength anomalous diffraction phasing, we determined the crystal structure of the OLF domain. This structure is a five-bladed beta propeller with a Ca2+ ion bound in the central pore, which is capped by a mobile loop that allows the ion to exchange with the solvent. The crystal structure of the OLF/FLRT3 complex shows that LPHN3-OLF in the closed state binds with high affinity to the concave face of FLRT3-LRR with a combination of hydrophobic and charged residues. Our study provides structural and functional insights into the molecular mechanism underlying the contribution of LPHN3/FLRT3 to the development of glutamatergic synapses.
-
Authors: Ranaivoson, F.M., Liu, Q., Martini, F., Bergami, F., Von daake, S., Li, S., Demeler, B., Hendrickson, W.A., Comoletti, D.
+
Structural and Mechanistic Insights into the Latrophilin3-FLRT3 Complex that Mediates Glutamatergic Synapse Development.,Ranaivoson FM, Liu Q, Martini F, Bergami F, von Daake S, Li S, Lee D, Demeler B, Hendrickson WA, Comoletti D Structure. 2015 Jul 28. pii: S0969-2126(15)00275-0. doi:, 10.1016/j.str.2015.06.022. PMID:26235031<ref>PMID:26235031</ref>
-
Description: Crystal structure of the Olfactomedin domain of latrophilin 3 in C2221 crystal form
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
[[Category: Unreleased Structures]]
+
</div>
-
[[Category: Li, S]]
+
<div class="pdbe-citations 4rml" style="background-color:#fffaf0;"></div>
-
[[Category: Liu, Q]]
+
 
-
[[Category: Comoletti, D]]
+
==See Also==
-
[[Category: Martini, F]]
+
*[[Latrophilin|Latrophilin]]
-
[[Category: Demeler, B]]
+
== References ==
-
[[Category: Bergami, F]]
+
<references/>
-
[[Category: Hendrickson, W.A]]
+
__TOC__
-
[[Category: Von Daake, S]]
+
</StructureSection>
-
[[Category: Ranaivoson, F.M]]
+
[[Category: Large Structures]]
 +
[[Category: Mus musculus]]
 +
[[Category: Bergami F]]
 +
[[Category: Comoletti D]]
 +
[[Category: Demeler B]]
 +
[[Category: Hendrickson WA]]
 +
[[Category: Li S]]
 +
[[Category: Liu Q]]
 +
[[Category: Martini F]]
 +
[[Category: Ranaivoson FM]]
 +
[[Category: Von daake S]]

Current revision

Crystal structure of the Olfactomedin domain of latrophilin 3 in C2221 crystal form

PDB ID 4rml

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4rml"
Personal tools