3ndb

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==Crystal structure of a signal sequence bound to the signal recognition particle==
==Crystal structure of a signal sequence bound to the signal recognition particle==
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<StructureSection load='3ndb' size='340' side='right' caption='[[3ndb]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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<StructureSection load='3ndb' size='340' side='right'caption='[[3ndb]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ndb]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NDB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NDB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ndb]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii] and [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii_DSM_2661 Methanocaldococcus jannaschii DSM 2661]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NDB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NDB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2v3c|2v3c]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MJ1034, srp19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 Methanocaldococcus jannaschii]), MJ0101, srp54 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 Methanocaldococcus jannaschii])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ndb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ndb OCA], [https://pdbe.org/3ndb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ndb RCSB], [https://www.ebi.ac.uk/pdbsum/3ndb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ndb ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ndb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ndb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ndb RCSB], [http://www.ebi.ac.uk/pdbsum/3ndb PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SRP19_METJA SRP19_METJA]] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP (By similarity). [[http://www.uniprot.org/uniprot/SRP54_METJA SRP54_METJA]] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.[HAMAP-Rule:MF_00306]
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[https://www.uniprot.org/uniprot/SRP19_METJA SRP19_METJA] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The signal recognition particle (SRP) recognizes and binds the signal sequence of nascent proteins as they emerge from the ribosome. We present here the 3.0-A structure of a signal sequence bound to the Methanococcus jannaschii SRP core. Structural comparison with the free SRP core shows that signal-sequence binding induces formation of the GM-linker helix and a 180 degrees flip of the NG domain-structural changes that ensure a hierarchical succession of events during protein targeting.
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Structural basis of signal-sequence recognition by the signal recognition particle.,Hainzl T, Huang S, Merilainen G, Brannstrom K, Sauer-Eriksson AE Nat Struct Mol Biol. 2011 Mar;18(3):389-91. Epub 2011 Feb 20. PMID:21336278<ref>PMID:21336278</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==See Also==
==See Also==
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*[[Signal recognition particle protein|Signal recognition particle protein]]
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*[[Signal recognition particle 3D structures|Signal recognition particle 3D structures]]
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Methanocaldococcus jannaschii]]
[[Category: Methanocaldococcus jannaschii]]
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[[Category: Hainzl, T]]
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[[Category: Methanocaldococcus jannaschii DSM 2661]]
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[[Category: Huang, S]]
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[[Category: Hainzl T]]
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[[Category: Sauer-Eriksson, E]]
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[[Category: Huang S]]
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[[Category: Protein-rna complex]]
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[[Category: Sauer-Eriksson E]]
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[[Category: Ribonucleoprotein]]
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[[Category: Signal recognition particle]]
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[[Category: Signal sequence]]
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[[Category: Signaling protein-rna complex]]
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Current revision

Crystal structure of a signal sequence bound to the signal recognition particle

PDB ID 3ndb

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