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1yb5

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[[Image:1yb5.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of human Zeta-Crystallin with bound NADP==
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|PDB= 1yb5 |SIZE=350|CAPTION= <scene name='initialview01'>1yb5</scene>, resolution 1.85&Aring;
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<StructureSection load='1yb5' size='340' side='right'caption='[[1yb5]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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<table><tr><td colspan='2'>[[1yb5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YB5 FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/NADPH:quinone_reductase NADPH:quinone reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.5.5 1.6.5.5]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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|GENE= CRYZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yb5 OCA], [https://pdbe.org/1yb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yb5 RCSB], [https://www.ebi.ac.uk/pdbsum/1yb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yb5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/QOR_HUMAN QOR_HUMAN] Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding.<ref>PMID:17497241</ref> <ref>PMID:20103721</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yb/1yb5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yb5 ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of human Zeta-Crystallin with bound NADP'''
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==See Also==
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*[[Quinone reductase 3D structures|Quinone reductase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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1YB5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YB5 OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: NADPH:quinone reductase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Arrowsmith C]]
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[[Category: Arrowsmith, C.]]
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[[Category: Berridge G]]
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[[Category: Berridge, G.]]
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[[Category: Bray J]]
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[[Category: Bray, J.]]
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[[Category: Colbrook S]]
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[[Category: Colbrook, S.]]
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[[Category: Debreczeni J]]
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[[Category: Debreczeni, J.]]
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[[Category: Edwards A]]
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[[Category: Delft, F von.]]
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[[Category: Gileadi O]]
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[[Category: Edwards, A.]]
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[[Category: Kavanagh K]]
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[[Category: Gileadi, O.]]
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[[Category: Oppermann U]]
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[[Category: Kavanagh, K.]]
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[[Category: Sundstrom M]]
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[[Category: Oppermann, U.]]
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[[Category: Williams L]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Von Delft F]]
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[[Category: Sundstrom, M.]]
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[[Category: Williams, L.]]
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[[Category: ACT]]
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[[Category: CL]]
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[[Category: GOL]]
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[[Category: NAP]]
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[[Category: medium-chain dehydrogenase/reductase]]
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[[Category: oxidoreductase]]
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[[Category: quinone reduction]]
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[[Category: sgc]]
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[[Category: structural genomic]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:20:39 2008''
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Current revision

Crystal structure of human Zeta-Crystallin with bound NADP

PDB ID 1yb5

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