1ykc

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[[Image:1ykc.gif|left|200px]]
 
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{{Structure
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==human glutathione S-transferase m2-2 (E.C.2.5.1.18) complexed with glutathione-disulfide==
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|PDB= 1ykc |SIZE=350|CAPTION= <scene name='initialview01'>1ykc</scene>, resolution 2.10&Aring;
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<StructureSection load='1ykc' size='340' side='right'caption='[[1ykc]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=GDS:OXIDIZED GLUTATHIONE DISULFIDE'>GDS</scene>
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<table><tr><td colspan='2'>[[1ykc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YKC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YKC FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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|GENE= GSTM2, GST4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDS:OXIDIZED+GLUTATHIONE+DISULFIDE'>GDS</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ykc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ykc OCA], [https://pdbe.org/1ykc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ykc RCSB], [https://www.ebi.ac.uk/pdbsum/1ykc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ykc ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GSTM2_HUMAN GSTM2_HUMAN] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.<ref>PMID:16549767</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yk/1ykc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ykc ConSurf].
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<div style="clear:both"></div>
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'''human glutathione S-transferase m2-2 (E.C.2.5.1.18) complexed with glutathione-disulfide'''
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==See Also==
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*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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1YKC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YKC OCA].
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__TOC__
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[[Category: Glutathione transferase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Almo, S C.]]
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[[Category: Almo SC]]
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[[Category: Listowsky, I.]]
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[[Category: Listowsky I]]
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[[Category: Patskovska, L N.]]
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[[Category: Patskovska LN]]
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[[Category: Patskovsky, Y V.]]
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[[Category: Patskovsky YV]]
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[[Category: GDS]]
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[[Category: conjugation]]
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[[Category: glutathione]]
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[[Category: glutathione-disulfide]]
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[[Category: prostaglandin e2]]
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[[Category: synthase]]
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[[Category: transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:24:15 2008''
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Current revision

human glutathione S-transferase m2-2 (E.C.2.5.1.18) complexed with glutathione-disulfide

PDB ID 1ykc

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OCA

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