1ypn

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[[Image:1ypn.jpg|left|200px]]
 
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{{Structure
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==REDUCED FORM HYDROXYMETHYLBILANE SYNTHASE (K59Q MUTANT) CRYSTAL STRUCTURE AFTER 2 HOURS IN A FLOW CELL DETERMINED BY TIME-RESOLVED LAUE DIFFRACTION==
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|PDB= 1ypn |SIZE=350|CAPTION= <scene name='initialview01'>1ypn</scene>, resolution 2.3&Aring;
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<StructureSection load='1ypn' size='340' side='right'caption='[[1ypn]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=DPM:3-{2-[4-(2-CARBOXY-ETHYL)-3-CARBOXYMETHYL-5H-PYRROL-2-YLMETHYL]-4-CARBOXYMETHYL-5-METHYL-2H-PYRROL-3-YL}-PROPIONIC ACID'>DPM</scene>
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<table><tr><td colspan='2'>[[1ypn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YPN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YPN FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Hydroxymethylbilane_synthase Hydroxymethylbilane synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.61 2.5.1.61]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DPM:3-[5-{[3-(2-CARBOXYETHYL)-4-(CARBOXYMETHYL)-5-METHYL-1H-PYRROL-2-YL]METHYL}-4-(CARBOXYMETHYL)-1H-PYRROL-3-YL]PROPANOIC+ACID'>DPM</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ypn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ypn OCA], [https://pdbe.org/1ypn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ypn RCSB], [https://www.ebi.ac.uk/pdbsum/1ypn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ypn ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HEM3_ECOLI HEM3_ECOLI] Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.[HAMAP-Rule:MF_00260]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yp/1ypn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ypn ConSurf].
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<div style="clear:both"></div>
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'''REDUCED FORM HYDROXYMETHYLBILANE SYNTHASE (K59Q MUTANT) CRYSTAL STRUCTURE AFTER 2 HOURS IN A FLOW CELL DETERMINED BY TIME-RESOLVED LAUE DIFFRACTION'''
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==See Also==
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*[[Porphobilinogen Deaminase|Porphobilinogen Deaminase]]
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__TOC__
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==About this Structure==
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</StructureSection>
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1YPN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YPN OCA].
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Hydroxymethylbilane synthase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Carr PD]]
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[[Category: Carr, P D.]]
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[[Category: Cassetta A]]
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[[Category: Cassetta, A.]]
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[[Category: Habash J]]
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[[Category: Habash, J.]]
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[[Category: Haedener A]]
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[[Category: Haedener, A.]]
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[[Category: Helliwell JR]]
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[[Category: Helliwell, J R.]]
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[[Category: Nieh YP]]
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[[Category: Nieh, Y P.]]
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[[Category: Niemann AC]]
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[[Category: Niemann, A C.]]
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[[Category: Raftery J]]
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[[Category: Raftery, J.]]
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[[Category: Thompson AW]]
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[[Category: Thompson, A W.]]
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[[Category: Ursby T]]
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[[Category: Ursby, T.]]
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[[Category: Wulff M]]
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[[Category: Wulff, M.]]
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[[Category: DPM]]
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[[Category: all alpha/beta]]
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[[Category: biosynthesis of linear tetrapyrrole]]
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[[Category: lyase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:25:54 2008''
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Current revision

REDUCED FORM HYDROXYMETHYLBILANE SYNTHASE (K59Q MUTANT) CRYSTAL STRUCTURE AFTER 2 HOURS IN A FLOW CELL DETERMINED BY TIME-RESOLVED LAUE DIFFRACTION

PDB ID 1ypn

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