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4ncr

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==Crystal structure of M. tuberculosis DprE1 in complex with PBTZ169==
==Crystal structure of M. tuberculosis DprE1 in complex with PBTZ169==
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<StructureSection load='4ncr' size='340' side='right' caption='[[4ncr]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
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<StructureSection load='4ncr' size='340' side='right'caption='[[4ncr]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ncr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NCR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NCR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ncr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NCR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NCR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=26J:2-(4-(CYCLOHEXYLMETHYL)PIPERAZIN-1-YL)-8-NITRO-6-(TRIFLUOROMETHYL)-4H-BENZO[E][1,3]THIAZIN-4-ONE,+BOUND+FORM'>26J</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.881&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4fdp|4fdp]], [[4f4q|4f4q]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=26J:2-(4-(CYCLOHEXYLMETHYL)PIPERAZIN-1-YL)-8-NITRO-6-(TRIFLUOROMETHYL)-4H-BENZO[E][1,3]THIAZIN-4-ONE,+BOUND+FORM'>26J</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dprE1, MT3898, Rv3790 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ncr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ncr OCA], [https://pdbe.org/4ncr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ncr RCSB], [https://www.ebi.ac.uk/pdbsum/4ncr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ncr ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ncr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ncr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ncr RCSB], [http://www.ebi.ac.uk/pdbsum/4ncr PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DPRE1_MYCTU DPRE1_MYCTU]] Involved in the epimerization of decaprenylphosphoryl ribose (DPR) to decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Probably catalyzes the oxidation at C-2 of decaprenylphosphoryl ribose (DPR) to yield decaprenylphosphoryl 2-keto-ribose (DPX).<ref>PMID:16291675</ref>
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[https://www.uniprot.org/uniprot/DPRE1_MYCTU DPRE1_MYCTU] Involved in the epimerization of decaprenylphosphoryl ribose (DPR) to decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Probably catalyzes the oxidation at C-2 of decaprenylphosphoryl ribose (DPR) to yield decaprenylphosphoryl 2-keto-ribose (DPX).<ref>PMID:16291675</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4ncr" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Myctu]]
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[[Category: Large Structures]]
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[[Category: Cole, S T]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Neres, J]]
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[[Category: Cole ST]]
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[[Category: Pojer, F]]
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[[Category: Neres J]]
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[[Category: Decaprenylphosphoryl-beta-d-ribose oxidase]]
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[[Category: Pojer F]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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Current revision

Crystal structure of M. tuberculosis DprE1 in complex with PBTZ169

PDB ID 4ncr

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