4ani

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==Structural basis for the intermolecular communication between DnaK and GrpE in the DnaK chaperone system from Geobacillus kaustophilus HTA426==
==Structural basis for the intermolecular communication between DnaK and GrpE in the DnaK chaperone system from Geobacillus kaustophilus HTA426==
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<StructureSection load='4ani' size='340' side='right' caption='[[4ani]], [[Resolution|resolution]] 4.09&Aring;' scene=''>
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<StructureSection load='4ani' size='340' side='right'caption='[[4ani]], [[Resolution|resolution]] 4.09&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ani]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Geobacillus_kaustophilus Geobacillus kaustophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ANI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ANI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ani]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_kaustophilus_HTA426 Geobacillus kaustophilus HTA426]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ANI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ANI FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2v7y|2v7y]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.094&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ani FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ani OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ani RCSB], [http://www.ebi.ac.uk/pdbsum/4ani PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ani FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ani OCA], [https://pdbe.org/4ani PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ani RCSB], [https://www.ebi.ac.uk/pdbsum/4ani PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ani ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GRPE_GEOKA GRPE_GEOKA]] Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding (By similarity). [[http://www.uniprot.org/uniprot/DNAK_GEOKA DNAK_GEOKA]] Acts as a chaperone (By similarity).
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[https://www.uniprot.org/uniprot/GRPE_GEOKA GRPE_GEOKA] Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4ani" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Geobacillus kaustophilus]]
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[[Category: Geobacillus kaustophilus HTA426]]
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[[Category: Chang, Y W]]
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[[Category: Large Structures]]
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[[Category: Chien, C H]]
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[[Category: Chang Y-W]]
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[[Category: Hsiao, C D]]
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[[Category: Chien C-H]]
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[[Category: Naveen, V]]
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[[Category: Hsiao C-D]]
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[[Category: Wu, C C]]
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[[Category: Naveen V]]
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[[Category: Chaperone]]
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[[Category: Wu C-C]]
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[[Category: Chaperone cycle]]
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[[Category: Complementary assay]]
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Current revision

Structural basis for the intermolecular communication between DnaK and GrpE in the DnaK chaperone system from Geobacillus kaustophilus HTA426

PDB ID 4ani

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