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3oes
From Proteopedia
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==Crystal structure of the small GTPase RhebL1== | ==Crystal structure of the small GTPase RhebL1== | ||
| - | <StructureSection load='3oes' size='340' side='right' caption='[[3oes]], [[Resolution|resolution]] 2.30Å' scene=''> | + | <StructureSection load='3oes' size='340' side='right'caption='[[3oes]], [[Resolution|resolution]] 2.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3oes]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3oes]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OES OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OES FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.301Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oes OCA], [https://pdbe.org/3oes PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oes RCSB], [https://www.ebi.ac.uk/pdbsum/3oes PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oes ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/REBL1_HUMAN REBL1_HUMAN] Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2.<ref>PMID:16328882</ref> <ref>PMID:12869548</ref> <ref>PMID:16098514</ref> <ref>PMID:17162089</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oe/3oes_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oe/3oes_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3oes ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
== References == | == References == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Arrowsmith | + | [[Category: Large Structures]] |
| - | [[Category: Bochkarev | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Bountra | + | [[Category: Bochkarev A]] |
| - | [[Category: Edwards | + | [[Category: Bountra C]] |
| - | [[Category: Loppnau | + | [[Category: Edwards AM]] |
| - | [[Category: Nedyalkova | + | [[Category: Loppnau P]] |
| - | [[Category: Park | + | [[Category: Nedyalkova L]] |
| - | + | [[Category: Park H]] | |
| - | [[Category: Shen | + | [[Category: Shen L]] |
| - | [[Category: Tempel | + | [[Category: Tempel W]] |
| - | [[Category: Tong | + | [[Category: Tong Y]] |
| - | [[Category: Weigelt | + | [[Category: Weigelt J]] |
| - | [[Category: Zhong | + | [[Category: Zhong N]] |
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Current revision
Crystal structure of the small GTPase RhebL1
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bochkarev A | Bountra C | Edwards AM | Loppnau P | Nedyalkova L | Park H | Shen L | Tempel W | Tong Y | Weigelt J | Zhong N
