1z3g

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:43, 30 October 2024) (edit) (undo)
 
(15 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1z3g.gif|left|200px]]
 
-
{{Structure
+
==Crystal structure of complex between Pvs25 and Fab fragment of malaria transmission blocking antibody 2A8==
-
|PDB= 1z3g |SIZE=350|CAPTION= <scene name='initialview01'>1z3g</scene>, resolution 3.3&Aring;
+
<StructureSection load='1z3g' size='340' side='right'caption='[[1z3g]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND=
+
<table><tr><td colspan='2'>[[1z3g]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Plasmodium_vivax_Sal-1 Plasmodium vivax Sal-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z3G FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
-
|GENE=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z3g OCA], [https://pdbe.org/1z3g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z3g RCSB], [https://www.ebi.ac.uk/pdbsum/1z3g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z3g ProSAT]</span></td></tr>
-
}}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/O96555_PLAVI O96555_PLAVI]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z3/1z3g_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z3g ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
P25 and P28 proteins are essential for Plasmodium parasites to infect mosquitoes and are leading candidates for a transmission-blocking malaria vaccine. The Plasmodium vivax P25 is a triangular prism that could tile the parasite surface. The residues forming the triangle are conserved in P25 and P28 from all Plasmodium species. A cocrystal structure shows that a transmission-blocking antibody uses only its heavy chain to bind Pvs25 at a vertex of the triangle.
-
'''Crystal structure of complex between Pvs25 and Fab fragment of malaria transmission blocking antibody 2A8'''
+
The essential mosquito-stage P25 and P28 proteins from Plasmodium form tile-like triangular prisms.,Saxena AK, Singh K, Su HP, Klein MM, Stowers AW, Saul AJ, Long CA, Garboczi DN Nat Struct Mol Biol. 2006 Jan;13(1):90-1. Epub 2005 Dec 4. PMID:16327807<ref>PMID:16327807</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 1z3g" style="background-color:#fffaf0;"></div>
-
==Overview==
+
==See Also==
-
P25 and P28 proteins are essential for Plasmodium parasites to infect mosquitoes and are leading candidates for a transmission-blocking malaria vaccine. The Plasmodium vivax P25 is a triangular prism that could tile the parasite surface. The residues forming the triangle are conserved in P25 and P28 from all Plasmodium species. A cocrystal structure shows that a transmission-blocking antibody uses only its heavy chain to bind Pvs25 at a vertex of the triangle.
+
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
1Z3G is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3G OCA].
+
__TOC__
-
 
+
</StructureSection>
-
==Reference==
+
[[Category: Large Structures]]
-
The essential mosquito-stage P25 and P28 proteins from Plasmodium form tile-like triangular prisms., Saxena AK, Singh K, Su HP, Klein MM, Stowers AW, Saul AJ, Long CA, Garboczi DN, Nat Struct Mol Biol. 2006 Jan;13(1):90-1. Epub 2005 Dec 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16327807 16327807]
+
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Plasmodium vivax]]
+
[[Category: Plasmodium vivax Sal-1]]
-
[[Category: Single protein]]
+
[[Category: Garboczi DN]]
-
[[Category: Garboczi, D N.]]
+
[[Category: Klein MM]]
-
[[Category: Klein, M M.]]
+
[[Category: Long CA]]
-
[[Category: Long, C A.]]
+
[[Category: Saul AJ]]
-
[[Category: Saul, A J.]]
+
[[Category: Saxena AK]]
-
[[Category: Saxena, A K.]]
+
[[Category: Singh K]]
-
[[Category: Singh, K.]]
+
[[Category: Stowers AW]]
-
[[Category: Stowers, A W.]]
+
[[Category: Su HP]]
-
[[Category: Su, H P.]]
+
-
[[Category: 2a8 fab]]
+
-
[[Category: pvs25]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:30:45 2008''
+

Current revision

Crystal structure of complex between Pvs25 and Fab fragment of malaria transmission blocking antibody 2A8

PDB ID 1z3g

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1z3g"
Personal tools