1z47

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[[Image:1z47.gif|left|200px]]
 
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{{Structure
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==Structure of the ATPase subunit CysA of the putative sulfate ATP-binding cassette (ABC) transporter from Alicyclobacillus acidocaldarius==
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|PDB= 1z47 |SIZE=350|CAPTION= <scene name='initialview01'>1z47</scene>, resolution 1.90&Aring;
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<StructureSection load='1z47' size='340' side='right'caption='[[1z47]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE ION'>CL</scene>
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<table><tr><td colspan='2'>[[1z47]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Alicyclobacillus_acidocaldarius Alicyclobacillus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z47 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z47 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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|GENE= cysA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=405212 Alicyclobacillus acidocaldarius])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z47 OCA], [https://pdbe.org/1z47 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z47 RCSB], [https://www.ebi.ac.uk/pdbsum/1z47 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z47 ProSAT]</span></td></tr>
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</table>
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'''Structure of the ATPase subunit CysA of the putative sulfate ATP-binding cassette (ABC) transporter from Alicyclobacillus acidocaldarius'''
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== Function ==
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[https://www.uniprot.org/uniprot/Q9RHZ7_ALIAC Q9RHZ7_ALIAC]
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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CysA, the ATPase subunit of a putative sulfate ATP-binding cassette transport system of the gram-positive thermoacidophilic bacterium Alicyclobacillus acidocaldarius, was structurally characterized at a resolution of 2.0 Angstroms in the absence of nucleotides. In line with previous findings on ABC-ATPases the structures of the two monomers (called CysA-1 and CysA-2) in the asymmetric unit differ substantially in the arrangement of their individual (sub)domains. CysA-2 was found as a physiological dimer composed of two crystallographically related monomers that are arranged in an open state. Interestingly, while the regulatory domain of CysA-2 packs against its opposing domain that of CysA-1 undergoes a conformational change and, in the dimer, would interfere with the opposing monomer thereby preventing solute translocation. Whether this conformational state is used for regulatory purposes will be discussed.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z4/1z47_consurf.spt"</scriptWhenChecked>
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1Z47 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Alicyclobacillus_acidocaldarius Alicyclobacillus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z47 OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Structure of the ATPase subunit CysA of the putative sulfate ATP-binding cassette (ABC) transporter from Alicyclobacillus acidocaldarius., Scheffel F, Demmer U, Warkentin E, Hulsmann A, Schneider E, Ermler U, FEBS Lett. 2005 May 23;579(13):2953-8. Epub 2005 Apr 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15893314 15893314]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z47 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Alicyclobacillus acidocaldarius]]
[[Category: Alicyclobacillus acidocaldarius]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Demmer, U.]]
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[[Category: Demmer U]]
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[[Category: Ermler, U.]]
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[[Category: Ermler U]]
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[[Category: Huelsmann, A.]]
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[[Category: Huelsmann A]]
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[[Category: Scheffel, F.]]
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[[Category: Scheffel F]]
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[[Category: Schneider, E.]]
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[[Category: Schneider E]]
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[[Category: Warkentin, E.]]
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[[Category: Warkentin E]]
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[[Category: CL]]
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[[Category: alpha/beta motif; beta sandwich]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:31:01 2008''
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Current revision

Structure of the ATPase subunit CysA of the putative sulfate ATP-binding cassette (ABC) transporter from Alicyclobacillus acidocaldarius

PDB ID 1z47

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