1z4r

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[[Image:1z4r.gif|left|200px]]
 
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{{Structure
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==Human GCN5 Acetyltransferase==
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|PDB= 1z4r |SIZE=350|CAPTION= <scene name='initialview01'>1z4r</scene>, resolution 1.74&Aring;
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<StructureSection load='1z4r' size='340' side='right'caption='[[1z4r]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ACO:ACETYL COENZYME *A'>ACO</scene>
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<table><tr><td colspan='2'>[[1z4r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z4R FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>
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|GENE= GCN5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z4r OCA], [https://pdbe.org/1z4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z4r RCSB], [https://www.ebi.ac.uk/pdbsum/1z4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z4r ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KAT2A_HUMAN KAT2A_HUMAN] Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Also acetylates non-histone proteins, such as CEBPB (PubMed:17301242). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.<ref>PMID:17301242</ref> <ref>PMID:19103755</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z4/1z4r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z4r ConSurf].
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<div style="clear:both"></div>
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'''Human GCN5 Acetyltransferase'''
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==See Also==
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*[[Histone acetyltransferase 3D structures|Histone acetyltransferase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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1Z4R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z4R OCA].
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__TOC__
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[[Category: Histone acetyltransferase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Antoshenko, T.]]
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[[Category: Antoshenko T]]
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[[Category: Arrowsmith, C.]]
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[[Category: Arrowsmith C]]
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[[Category: Bernstein, G.]]
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[[Category: Bernstein G]]
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[[Category: Bochkarev, A.]]
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[[Category: Bochkarev A]]
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[[Category: Dong, A.]]
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[[Category: Dong A]]
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[[Category: Edwards, A.]]
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[[Category: Edwards A]]
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[[Category: Loppnau, P.]]
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[[Category: Loppnau P]]
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[[Category: Plotnikov, A.]]
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[[Category: Plotnikov A]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Schuetz A]]
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[[Category: Schuetz, A.]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M.]]
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[[Category: Wu H]]
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[[Category: Wu, H.]]
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[[Category: ACO]]
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[[Category: acetyltransferase]]
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[[Category: gcn5]]
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[[Category: sgc]]
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[[Category: structural genomic]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:31:11 2008''
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Current revision

Human GCN5 Acetyltransferase

PDB ID 1z4r

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