This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4g5q

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:51, 20 March 2024) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
 +
==Structure of LGN GL4/Galphai1 complex==
==Structure of LGN GL4/Galphai1 complex==
-
<StructureSection load='4g5q' size='340' side='right' caption='[[4g5q]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
+
<StructureSection load='4g5q' size='340' side='right'caption='[[4g5q]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4g5q]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G5Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G5Q FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4g5q]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G5Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G5Q FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4g5o|4g5o]], [[4g5r|4g5r]], [[4g5s|4g5s]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GNAI1, GNAI3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g5q OCA], [https://pdbe.org/4g5q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g5q RCSB], [https://www.ebi.ac.uk/pdbsum/4g5q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g5q ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g5q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g5q RCSB], [http://www.ebi.ac.uk/pdbsum/4g5q PDBsum]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref> [[http://www.uniprot.org/uniprot/GPSM2_MOUSE GPSM2_MOUSE]] Plays an important role in spindle pole orientation (By similarity). Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions.
+
[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref>
-
 
+
-
==See Also==
+
-
*[[Guanine nucleotide-binding protein|Guanine nucleotide-binding protein]]
+
== References ==
== References ==
<references/>
<references/>
Line 18: Line 15:
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Jia, M]]
+
[[Category: Large Structures]]
-
[[Category: Li, J]]
+
[[Category: Mus musculus]]
-
[[Category: Wang, W]]
+
[[Category: Jia M]]
-
[[Category: Wen, W]]
+
[[Category: Li J]]
-
[[Category: Zhang, M]]
+
[[Category: Wang W]]
-
[[Category: Zhu, J]]
+
[[Category: Wen W]]
-
[[Category: Asymmetric cell division]]
+
[[Category: Zhang M]]
-
[[Category: Cell cycle-signaling protein complex]]
+
[[Category: Zhu J]]
-
[[Category: Galpha signaling]]
+
-
[[Category: Galphai]]
+
-
[[Category: Goloco]]
+

Current revision

Structure of LGN GL4/Galphai1 complex

PDB ID 4g5q

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4g5q"
Personal tools