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4wl8
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Mtb PEPCK in complex with non-hydrolyzable analog of GTP== | |
| + | <StructureSection load='4wl8' size='340' side='right'caption='[[4wl8]], [[Resolution|resolution]] 1.61Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4wl8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Ra Mycobacterium tuberculosis H37Ra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WL8 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.61Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wl8 OCA], [https://pdbe.org/4wl8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wl8 RCSB], [https://www.ebi.ac.uk/pdbsum/4wl8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wl8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PCKG_MYCTA PCKG_MYCTA] Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. | ||
| - | + | ==See Also== | |
| - | + | *[[Phosphoenolpyruvate carboxykinase 3D structures|Phosphoenolpyruvate carboxykinase 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Kim | + | [[Category: Mycobacterium tuberculosis H37Ra]] |
| + | [[Category: Kim HL]] | ||
| + | [[Category: Sacchettini JC]] | ||
Current revision
Crystal Structure of Mtb PEPCK in complex with non-hydrolyzable analog of GTP
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