4wm7

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'''Unreleased structure'''
 
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The entry 4wm7 is ON HOLD until Paper Publication
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==Crystal Structure of Human Enterovirus D68 in Complex with Pleconaril==
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<StructureSection load='4wm7' size='340' side='right'caption='[[4wm7]], [[Resolution|resolution]] 2.32&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4wm7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterovirus_D68 Enterovirus D68]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WM7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WM7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.32&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=W11:3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE'>W11</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wm7 OCA], [https://pdbe.org/4wm7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wm7 RCSB], [https://www.ebi.ac.uk/pdbsum/4wm7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wm7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9YLJ3_HED68 Q9YLJ3_HED68]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Enterovirus D68 (EV-D68) is a member of Picornaviridae and is a causative agent of recent outbreaks of respiratory illness in children in the United States. We report here the crystal structures of EV-D68 and its complex with pleconaril, a capsid-binding compound that had been developed as an anti-rhinovirus drug. The hydrophobic drug-binding pocket in viral protein 1 contained density that is consistent with a fatty acid of about 10 carbon atoms. This density could be displaced by pleconaril. We also showed that pleconaril inhibits EV-D68 at a half-maximal effective concentration of 430 nanomolar and might, therefore, be a possible drug candidate to alleviate EV-D68 outbreaks.
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Authors: Liu, Y., Sheng, J., Fokine, A., Meng, G., Long, F., Kuhn, R.J., Rossmann, M.G.
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Virus structure. Structure and inhibition of EV-D68, a virus that causes respiratory illness in children.,Liu Y, Sheng J, Fokine A, Meng G, Shin WH, Long F, Kuhn RJ, Kihara D, Rossmann MG Science. 2015 Jan 2;347(6217):71-4. doi: 10.1126/science.1261962. PMID:25554786<ref>PMID:25554786</ref>
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Description: Crystal Structure of Human Enterovirus D68 in Complex with Pleconaril
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Fokine, A]]
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<div class="pdbe-citations 4wm7" style="background-color:#fffaf0;"></div>
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[[Category: Kuhn, R.J]]
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[[Category: Liu, Y]]
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==See Also==
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[[Category: Meng, G]]
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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[[Category: Rossmann, M.G]]
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== References ==
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[[Category: Sheng, J]]
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<references/>
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[[Category: Long, F]]
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__TOC__
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</StructureSection>
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[[Category: Enterovirus D68]]
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[[Category: Large Structures]]
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[[Category: Fokine A]]
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[[Category: Kuhn RJ]]
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[[Category: Liu Y]]
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[[Category: Long F]]
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[[Category: Meng G]]
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[[Category: Rossmann MG]]
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[[Category: Sheng J]]

Current revision

Crystal Structure of Human Enterovirus D68 in Complex with Pleconaril

PDB ID 4wm7

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