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4ww7

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'''Unreleased structure'''
 
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The entry 4ww7 is ON HOLD
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==Crystal structure of binary complex Bud32-Cgi121 in complex with AMP==
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<StructureSection load='4ww7' size='340' side='right'caption='[[4ww7]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
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Authors: Zhang, W., van Tilbeurgh, H.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ww7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WW7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WW7 FirstGlance]. <br>
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Description: Crystal structure of binary complex Bud32-Cgi121 in complex with AMP
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.669&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Zhang, W]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ww7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ww7 OCA], [https://pdbe.org/4ww7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ww7 RCSB], [https://www.ebi.ac.uk/pdbsum/4ww7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ww7 ProSAT]</span></td></tr>
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[[Category: Van Tilbeurgh, H]]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BUD32_YEAST BUD32_YEAST] Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. Important for bud site selection.<ref>PMID:16564010</ref> <ref>PMID:16874308</ref> <ref>PMID:21183954</ref> <ref>PMID:21459853</ref> <ref>PMID:23258706</ref> <ref>PMID:23620299</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Zhang W]]
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[[Category: Van Tilbeurgh H]]

Current revision

Crystal structure of binary complex Bud32-Cgi121 in complex with AMP

PDB ID 4ww7

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