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3pfp

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==Structure of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis in complex with an active site inhibitor==
==Structure of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis in complex with an active site inhibitor==
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<StructureSection load='3pfp' size='340' side='right' caption='[[3pfp]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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<StructureSection load='3pfp' size='340' side='right'caption='[[3pfp]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3pfp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PFP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PFP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3pfp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PFP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=035:(2S)-2,7-BIS(PHOSPHONOOXY)HEPTANOIC+ACID'>035</scene>, <scene name='pdbligand=036:(2R)-2,7-BIS(PHOSPHONOOXY)HEPTANOIC+ACID'>036</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2b7o|2b7o]], [[3nv8|3nv8]], [[3kgf|3kgf]], [[3nud|3nud]], [[3nue|3nue]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=035:(2S)-2,7-BIS(PHOSPHONOOXY)HEPTANOIC+ACID'>035</scene>, <scene name='pdbligand=036:(2R)-2,7-BIS(PHOSPHONOOXY)HEPTANOIC+ACID'>036</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">aroG, Rv2178c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pfp OCA], [https://pdbe.org/3pfp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pfp RCSB], [https://www.ebi.ac.uk/pdbsum/3pfp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pfp ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-deoxy-7-phosphoheptulonate_synthase 3-deoxy-7-phosphoheptulonate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.54 2.5.1.54] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pfp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pfp RCSB], [http://www.ebi.ac.uk/pdbsum/3pfp PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/O53512_MYCTU O53512_MYCTU]] Catalyzes an aldol-like condensation reaction between phosphoenolpyruvate (PEP) and D-erythrose 4-phosphate (E4P) to generate 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAH7P) and inorganic phosphate.<ref>PMID:16288916</ref>
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[https://www.uniprot.org/uniprot/AROG_MYCTU AROG_MYCTU] Catalyzes an aldol-like condensation reaction between phosphoenolpyruvate (PEP) and D-erythrose 4-phosphate (E4P) to generate 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAH7P) and inorganic phosphate.<ref>PMID:16288916</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3pfp" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[DAHP synthase 3D structures|DAHP synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 3-deoxy-7-phosphoheptulonate synthase]]
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[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Baker, E N]]
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[[Category: Baker EN]]
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[[Category: Hutton, R D]]
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[[Category: Hutton RD]]
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[[Category: Jiao, W]]
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[[Category: Jiao W]]
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[[Category: Parker, E J]]
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[[Category: Parker EJ]]
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[[Category: Reichau, S]]
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[[Category: Reichau S]]
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[[Category: Walker, S R]]
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[[Category: Walker SR]]
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[[Category: Aromatic biosynthesis]]
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[[Category: Dah7p synthase]]
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[[Category: Shikimate pathway]]
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[[Category: Tim barrel]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Structure of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis in complex with an active site inhibitor

PDB ID 3pfp

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