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3ews

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==Human DEAD-box RNA-helicase DDX19 in complex with ADP==
==Human DEAD-box RNA-helicase DDX19 in complex with ADP==
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<StructureSection load='3ews' size='340' side='right' caption='[[3ews]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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<StructureSection load='3ews' size='340' side='right'caption='[[3ews]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ews]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EWS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EWS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ews]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EWS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EWS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DBP5, DDX19, DDX19B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ews FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ews OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ews RCSB], [http://www.ebi.ac.uk/pdbsum/3ews PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ews FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ews OCA], [https://pdbe.org/3ews PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ews RCSB], [https://www.ebi.ac.uk/pdbsum/3ews PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ews ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DD19B_HUMAN DD19B_HUMAN]] ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins.
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[https://www.uniprot.org/uniprot/DD19B_HUMAN DD19B_HUMAN] ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ew/3ews_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ew/3ews_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ews ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3ews" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[DEAD-box RNA-helicase DDX19 in complex with ADP|DEAD-box RNA-helicase DDX19 in complex with ADP]]
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*[[Helicase 3D structures|Helicase 3D structures]]
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*[[Dead-box RNA helicase DDX19%2C in complex with an ATP-analogue and RNA|Dead-box RNA helicase DDX19%2C in complex with an ATP-analogue and RNA]]
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*[[Helicase|Helicase]]
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== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Andersson,j]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith,c h]]
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[[Category: Andersson j]]
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[[Category: Berglund,h]]
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[[Category: Arrowsmith ch]]
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[[Category: Bountra, c]]
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[[Category: Berglund h]]
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[[Category: Collins,r]]
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[[Category: Bountra c]]
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[[Category: Dahlgren,l g]]
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[[Category: Collins r]]
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[[Category: Edwards,a m]]
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[[Category: Dahlgren lg]]
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[[Category: Flodin,s]]
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[[Category: Edwards am]]
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[[Category: Flores,a]]
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[[Category: Flodin s]]
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[[Category: Graslund,s]]
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[[Category: Flores a]]
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[[Category: Hammarstrom,m]]
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[[Category: Graslund s]]
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[[Category: Johansson,a]]
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[[Category: Hammarstrom m]]
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[[Category: Johansson,i]]
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[[Category: Johansson a]]
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[[Category: Karlberg,t]]
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[[Category: Johansson i]]
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[[Category: Kotenyova,t]]
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[[Category: Karlberg t]]
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[[Category: Lehtio,l]]
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[[Category: Kotenyova t]]
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[[Category: Moche,m]]
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[[Category: Lehtio l]]
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[[Category: Nilsson,m e]]
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[[Category: Moche m]]
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[[Category: Nordlund,p]]
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[[Category: Nilsson me]]
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[[Category: Nyman,t]]
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[[Category: Nordlund p]]
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[[Category: Olesen,k]]
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[[Category: Nyman t]]
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[[Category: Persson,c]]
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[[Category: Olesen k]]
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[[Category: Structural genomic]]
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[[Category: Persson c]]
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[[Category: Sagemark,j]]
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[[Category: Sagemark j]]
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[[Category: Schueler,h]]
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[[Category: Schueler h]]
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[[Category: Thorsell,a g]]
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[[Category: Thorsell ag]]
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[[Category: Tresaugues,l]]
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[[Category: Tresaugues l]]
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[[Category: Weigelt, j]]
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[[Category: Van den berg s]]
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[[Category: Welin,m]]
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[[Category: Weigelt j]]
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[[Category: Wikstrom,m]]
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[[Category: Welin m]]
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[[Category: Wisniewska,m]]
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[[Category: Wikstrom m]]
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[[Category: Berg, s Van den]]
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[[Category: Wisniewska m]]
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[[Category: Adp]]
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[[Category: Atp-binding]]
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[[Category: Dead]]
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[[Category: Helicase]]
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[[Category: Hydrolase]]
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[[Category: Membrane]]
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[[Category: Mrna]]
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[[Category: Mrna transport]]
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[[Category: Nuclear pore complex]]
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[[Category: Nucleotide-binding]]
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[[Category: Nucleus]]
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[[Category: Protein transport]]
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[[Category: Rna helicase]]
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[[Category: Rna-binding]]
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[[Category: Rrna]]
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[[Category: Sgc]]
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[[Category: Translocation]]
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[[Category: Transport]]
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Current revision

Human DEAD-box RNA-helicase DDX19 in complex with ADP

PDB ID 3ews

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