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4rbs
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==Crystal Structure of New Delhi Metallo-beta-Lactamase-1 in the Complex with Hydrolyzed Meropenem== | ==Crystal Structure of New Delhi Metallo-beta-Lactamase-1 in the Complex with Hydrolyzed Meropenem== | ||
| - | <StructureSection load='4rbs' size='340' side='right' caption='[[4rbs]], [[Resolution|resolution]] 2.41Å' scene=''> | + | <StructureSection load='4rbs' size='340' side='right'caption='[[4rbs]], [[Resolution|resolution]] 2.41Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4rbs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RBS OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4rbs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RBS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RBS FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0RV:(2S)-2-[(1S,2R)-1-CARBOXY-2-HYDROXYPROPYL]-4-{[(3S,5S)-5-(DIMETHYLCARBAMOYL)PYRROLIDIN-3-YL]SULFANYL}-3-METHYL-2H-PYRROLE-5-CARBOXYLIC+ACID'>0RV</scene>, <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.405Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0RV:(2S)-2-[(1S,2R)-1-CARBOXY-2-HYDROXYPROPYL]-4-{[(3S,5S)-5-(DIMETHYLCARBAMOYL)PYRROLIDIN-3-YL]SULFANYL}-3-METHYL-2H-PYRROLE-5-CARBOXYLIC+ACID'>0RV</scene>, <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rbs OCA], [https://pdbe.org/4rbs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rbs RCSB], [https://www.ebi.ac.uk/pdbsum/4rbs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rbs ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin. |
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| + | ==See Also== | ||
| + | *[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Klebsiella pneumoniae]] |
| - | [[Category: Babnigg | + | [[Category: Large Structures]] |
| - | [[Category: Jedrzejczak | + | [[Category: Babnigg G]] |
| - | [[Category: Joachimiak | + | [[Category: Jedrzejczak R]] |
| - | [[Category: Kim | + | [[Category: Joachimiak A]] |
| - | + | [[Category: Kim Y]] | |
| - | + | [[Category: Sacchettini J]] | |
| - | [[Category: Sacchettini | + | [[Category: Tesar C]] |
| - | [[Category: Tesar | + | |
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Current revision
Crystal Structure of New Delhi Metallo-beta-Lactamase-1 in the Complex with Hydrolyzed Meropenem
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