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3mkn

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==Crystal structure of the E. coli pyrimidine nucleosidase YeiK bound to a competitive inhibitor==
==Crystal structure of the E. coli pyrimidine nucleosidase YeiK bound to a competitive inhibitor==
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<StructureSection load='3mkn' size='340' side='right' caption='[[3mkn]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='3mkn' size='340' side='right'caption='[[3mkn]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3mkn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MKN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MKN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3mkn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MKN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MKN FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DNB:(2S,3S,4R,5R)-2-(3,4-DIAMINOPHENYL)-5-(HYDROXYMETHYL)PYRROLIDINE-3,4-DIOL'>DNB</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1q8f|1q8f]], [[3b9x|3b9x]], [[3mkm|3mkm]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DNB:(2S,3S,4R,5R)-2-(3,4-DIAMINOPHENYL)-5-(HYDROXYMETHYL)PYRROLIDINE-3,4-DIOL'>DNB</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">YeiK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mkn OCA], [https://pdbe.org/3mkn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mkn RCSB], [https://www.ebi.ac.uk/pdbsum/3mkn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mkn ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribosylpyrimidine_nucleosidase Ribosylpyrimidine nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.8 3.2.2.8] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mkn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mkn RCSB], [http://www.ebi.ac.uk/pdbsum/3mkn PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/C3T3U2_ECOLX C3T3U2_ECOLX]] Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively. Has a clear preference for cytidine over uridine. Strictly specific for ribonucleosides (By similarity).[HAMAP-Rule:MF_01433]
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[https://www.uniprot.org/uniprot/C3T3U2_ECOLX C3T3U2_ECOLX] Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively. Has a clear preference for cytidine over uridine. Strictly specific for ribonucleosides (By similarity).[HAMAP-Rule:MF_01433]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3mkn" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Escherichia coli]]
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[[Category: Escherichia coli K-12]]
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[[Category: Ribosylpyrimidine nucleosidase]]
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[[Category: Large Structures]]
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[[Category: Degano, M]]
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[[Category: Degano M]]
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[[Category: Fornili, A]]
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[[Category: Fornili A]]
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[[Category: Garau, G]]
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[[Category: Garau G]]
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[[Category: Giabbai, B]]
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[[Category: Giabbai B]]
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[[Category: Enzyme-inhibitor complex]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Metalloenzyme]]
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[[Category: Nucleotide metabolism]]
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[[Category: Pyrimidine nucleoside hydrolase]]
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Current revision

Crystal structure of the E. coli pyrimidine nucleosidase YeiK bound to a competitive inhibitor

PDB ID 3mkn

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