1zpq

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[[Image:1zpq.gif|left|200px]]
 
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{{Structure
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==STRUCTURE OF BACTERIOPHAGE LAMBDA CII protein==
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|PDB= 1zpq |SIZE=350|CAPTION= <scene name='initialview01'>1zpq</scene>, resolution 2.8&Aring;
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<StructureSection load='1zpq' size='340' side='right'caption='[[1zpq]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1zpq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_Lambda Escherichia virus Lambda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZPQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZPQ FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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|GENE= CII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10710 Enterobacteria phage lambda])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zpq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zpq OCA], [https://pdbe.org/1zpq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zpq RCSB], [https://www.ebi.ac.uk/pdbsum/1zpq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zpq ProSAT], [https://www.topsan.org/Proteins/MCSG/1zpq TOPSAN]</span></td></tr>
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}}
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</table>
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== Function ==
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'''STRUCTURE OF BACTERIOPHAGE LAMBDA CII protein'''
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[https://www.uniprot.org/uniprot/RPC2_LAMBD RPC2_LAMBD] This protein and protein CIII form a complex that is involved in the initiation of lysogeny. The complex binds at either of the cy regulatory sites preceding the CI repressor protein and integrase coding regions and induces transcription of these genes.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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The tetrameric cII protein from bacteriophage lambda activates transcription from the phage promoters P(RE), P(I), and P(AQ) by binding to two direct repeats that flank the promoter -35 element. Here, we present the X-ray crystal structure of cII alone (2.8 A resolution) and in complex with its DNA operator from P(RE) (1.7 A resolution). The structures provide a basis for modeling of the activation complex with the RNA polymerase holoenzyme, and point to the key role for the RNA polymerase alpha subunit C-terminal domain (alphaCTD) in cII-dependent activation, which forms a bridge of protein/protein interactions between cII and the RNA polymerase sigma subunit. The model makes specific predictions for protein/protein interactions between cII and alphaCTD, and between alphaCTD and sigma, which are supported by previous genetic studies.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zp/1zpq_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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1ZPQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_lambda Enterobacteria phage lambda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZPQ OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zpq ConSurf].
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Crystal structure of bacteriophage lambda cII and its DNA complex., Jain D, Kim Y, Maxwell KL, Beasley S, Zhang R, Gussin GN, Edwards AM, Darst SA, Mol Cell. 2005 Jul 22;19(2):259-69. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16039594 16039594]
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<div style="clear:both"></div>
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[[Category: Enterobacteria phage lambda]]
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__TOC__
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[[Category: Single protein]]
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</StructureSection>
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[[Category: Beasley, S.]]
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[[Category: Escherichia virus Lambda]]
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[[Category: Darst, S A.]]
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[[Category: Large Structures]]
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[[Category: Edwards, A M.]]
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[[Category: Beasley S]]
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[[Category: Gussin, G N.]]
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[[Category: Darst SA]]
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[[Category: Jain, D.]]
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[[Category: Edwards AM]]
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[[Category: Kim, Y.]]
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[[Category: Gussin GN]]
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[[Category: MCSG, Midwest Center for Structural Genomics.]]
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[[Category: Jain D]]
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[[Category: Maxwell, K L.]]
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[[Category: Joachimiak A]]
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[[Category: helix-turn-helix]]
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[[Category: Kim Y]]
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[[Category: mcsg]]
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[[Category: Maxwell KL]]
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[[Category: midwest center for structural genomic]]
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[[Category: protein structure initiative]]
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[[Category: psi]]
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[[Category: structural genomic]]
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[[Category: transcription activation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:38:21 2008''
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Current revision

STRUCTURE OF BACTERIOPHAGE LAMBDA CII protein

PDB ID 1zpq

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