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1zrh

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[[Image:1zrh.gif|left|200px]]
 
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{{Structure
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==Crystal structure of Human heparan sulfate glucosamine 3-O-sulfotransferase 1 in complex with PAP==
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|PDB= 1zrh |SIZE=350|CAPTION= <scene name='initialview01'>1zrh</scene>, resolution 2.10&Aring;
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<StructureSection load='1zrh' size='340' side='right'caption='[[1zrh]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=A3P:ADENOSINE-3'-5'-DIPHOSPHATE'>A3P</scene>
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<table><tr><td colspan='2'>[[1zrh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZRH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZRH FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/[Heparan_sulfate]-glucosamine_3-sulfotransferase_1 [Heparan sulfate]-glucosamine 3-sulfotransferase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.2.23 2.8.2.23]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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|GENE= HS3ST1, 3OST, 3OST1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zrh OCA], [https://pdbe.org/1zrh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zrh RCSB], [https://www.ebi.ac.uk/pdbsum/1zrh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zrh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HS3S1_HUMAN HS3S1_HUMAN] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site.<ref>PMID:9346953</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zr/1zrh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zrh ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of Human heparan sulfate glucosamine 3-O-sulfotransferase 1 in complex with PAP'''
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==See Also==
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*[[Sulfotransferase 3D structures|Sulfotransferase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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1ZRH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZRH OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: [Heparan sulfate]-glucosamine 3-sulfotransferase 1]]
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[[Category: Arrowsmith CH]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Bochkarev A]]
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[[Category: Bochkarev, A.]]
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[[Category: Dombrovski L]]
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[[Category: Dombrovski, L.]]
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[[Category: Dong A]]
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[[Category: Dong, A.]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A M.]]
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[[Category: Loppnau P]]
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[[Category: Loppnau, P.]]
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[[Category: Plotnikov AN]]
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[[Category: Plotnikov, A N.]]
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[[Category: Sundstrom M]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Sundstrom, M.]]
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[[Category: A3P]]
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[[Category: sgc; sulfotransferase hs3st1]]
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[[Category: structural genomic]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:38:59 2008''
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Current revision

Crystal structure of Human heparan sulfate glucosamine 3-O-sulfotransferase 1 in complex with PAP

PDB ID 1zrh

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