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4nn5

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==Cytokine receptor complex - Crystal form 1A==
==Cytokine receptor complex - Crystal form 1A==
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<StructureSection load='4nn5' size='340' side='right' caption='[[4nn5]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='4nn5' size='340' side='right'caption='[[4nn5]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4nn5]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NN5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NN5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4nn5]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NN5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NN5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.898&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4nn6|4nn6]], [[4nn7|4nn7]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tslp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Il7r, IL7RA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Crlf2, CRLF2 (TSLPR), Crlm2, Tpte2, Tslpr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nn5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nn5 OCA], [https://pdbe.org/4nn5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nn5 RCSB], [https://www.ebi.ac.uk/pdbsum/4nn5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nn5 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nn5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nn5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nn5 RCSB], [http://www.ebi.ac.uk/pdbsum/4nn5 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TSLP_MOUSE TSLP_MOUSE]] Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells (By similarity). [[http://www.uniprot.org/uniprot/CRLF2_MOUSE CRLF2_MOUSE]] Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system. [[http://www.uniprot.org/uniprot/IL7RA_MOUSE IL7RA_MOUSE]] Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
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[https://www.uniprot.org/uniprot/TSLP_MOUSE TSLP_MOUSE] Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4nn5" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Interleukin receptor 3D structures|Interleukin receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Savvides, S N]]
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[[Category: Mus musculus]]
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[[Category: Schie, L van]]
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[[Category: Savvides SN]]
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[[Category: Verstraete, K]]
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[[Category: Verstraete K]]
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[[Category: Cell surface]]
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[[Category: Van Schie L]]
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[[Category: Chr domain]]
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[[Category: Cytokine-cytokine receptor complex]]
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[[Category: Four helical bundle fold]]
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[[Category: Tslp cytokine signaling]]
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[[Category: Tslpr and il-7ralpha receptor]]
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Current revision

Cytokine receptor complex - Crystal form 1A

PDB ID 4nn5

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