2l3g

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:52, 1 May 2024) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Solution NMR Structure of CH domain of Rho guanine nucleotide exchange factor 7 from Homo sapiens, Northeast Structural Genomics Consortium Target HR4495E==
==Solution NMR Structure of CH domain of Rho guanine nucleotide exchange factor 7 from Homo sapiens, Northeast Structural Genomics Consortium Target HR4495E==
-
<StructureSection load='2l3g' size='340' side='right' caption='[[2l3g]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+
<StructureSection load='2l3g' size='340' side='right'caption='[[2l3g]]' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2l3g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L3G FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2l3g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L3G FirstGlance]. <br>
-
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB, Nbla10314 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l3g RCSB], [http://www.ebi.ac.uk/pdbsum/2l3g PDBsum]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3g OCA], [https://pdbe.org/2l3g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l3g RCSB], [https://www.ebi.ac.uk/pdbsum/2l3g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l3g ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/ARHG7_HUMAN ARHG7_HUMAN]] Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.<ref>PMID:19041750</ref> <ref>PMID:18716323</ref> <ref>PMID:18184567</ref>
+
[https://www.uniprot.org/uniprot/ARHG7_HUMAN ARHG7_HUMAN] Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.<ref>PMID:19041750</ref> <ref>PMID:18716323</ref> <ref>PMID:18184567</ref>
 +
 
 +
==See Also==
 +
*[[Rho guanine nucleotide exchange factor 3D structures|Rho guanine nucleotide exchange factor 3D structures]]
== References ==
== References ==
<references/>
<references/>
Line 13: Line 17:
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Acton, T B]]
+
[[Category: Large Structures]]
-
[[Category: Ciccosanti, A]]
+
[[Category: Acton TB]]
-
[[Category: Everett, J]]
+
[[Category: Ciccosanti A]]
-
[[Category: Janjua, H]]
+
[[Category: Everett J]]
-
[[Category: Liu, G]]
+
[[Category: Janjua H]]
-
[[Category: Montelione, G T]]
+
[[Category: Liu G]]
-
[[Category: Structural genomic]]
+
[[Category: Montelione GT]]
-
[[Category: Shastry, R]]
+
[[Category: Shastry R]]
-
[[Category: Xiao, R]]
+
[[Category: Xiao R]]
-
[[Category: Calponin-homology domain]]
+
-
[[Category: PSI, Protein structure initiative]]
+
-
[[Category: Psi-biology]]
+
-
[[Category: Signaling protein]]
+

Current revision

Solution NMR Structure of CH domain of Rho guanine nucleotide exchange factor 7 from Homo sapiens, Northeast Structural Genomics Consortium Target HR4495E

PDB ID 2l3g

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2l3g"
Personal tools