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3w9e

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==Structure of Human Monoclonal Antibody E317 Fab Complex with HSV-2 gD==
==Structure of Human Monoclonal Antibody E317 Fab Complex with HSV-2 gD==
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<StructureSection load='3w9e' size='340' side='right' caption='[[3w9e]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='3w9e' size='340' side='right'caption='[[3w9e]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3w9e]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Hhv-2 Hhv-2] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W9E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3W9E FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3w9e]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_herpesvirus_2_strain_HG52 Human herpesvirus 2 strain HG52]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W9E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W9E FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3w9d|3w9d]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10315 HHV-2])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w9e OCA], [https://pdbe.org/3w9e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w9e RCSB], [https://www.ebi.ac.uk/pdbsum/3w9e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w9e ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3w9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w9e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3w9e RCSB], [http://www.ebi.ac.uk/pdbsum/3w9e PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GD_HHV2H GD_HHV2H]] Envelope glycoprotein that binds to the potential host cell entry receptors TNFRSF14/HVEM, PVRL1 and PVRL1. May trigger fusion with host membrane, by recruiting the fusion machinery composed of gB and gH/gL (By similarity).
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[https://www.uniprot.org/uniprot/GD_HHV2H GD_HHV2H] Envelope glycoprotein that binds to the potential host cell entry receptors TNFRSF14/HVEM, PVRL1 and PVRL1. May trigger fusion with host membrane, by recruiting the fusion machinery composed of gB and gH/gL (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3w9e" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Monoclonal Antibody|Monoclonal Antibody]]
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*[[Glycoproteins B and D|Glycoproteins B and D]]
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*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Hhv-2]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Human herpesvirus 2 strain HG52]]
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[[Category: Lee, C C]]
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[[Category: Large Structures]]
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[[Category: Lin, L L]]
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[[Category: Lee CC]]
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[[Category: Wang, A H.J]]
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[[Category: Lin LL]]
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[[Category: Igg fold]]
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[[Category: Wang AHJ]]
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[[Category: Viral protein-immune system complex]]
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Current revision

Structure of Human Monoclonal Antibody E317 Fab Complex with HSV-2 gD

PDB ID 3w9e

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