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3zwo

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==Crystal structure of ADP ribosyl cyclase complexed with reaction intermediate==
==Crystal structure of ADP ribosyl cyclase complexed with reaction intermediate==
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<StructureSection load='3zwo' size='340' side='right' caption='[[3zwo]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='3zwo' size='340' side='right'caption='[[3zwo]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3zwo]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZWO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZWO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3zwo]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZWO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZWO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G2Q:GUANOSINE+DIPHOSPHATE+RIBOSE'>G2Q</scene>, <scene name='pdbligand=NGD:3-(AMINOCARBONYL)-1-[(2R,3R,4S,5R)-5-({[(S)-{[(S)-{[(2R,3S,4R,5R)-5-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]OXY}METHYL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]PYRIDINIUM'>NGD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1r0s|1r0s]], [[3zwn|3zwn]], [[1lbe|1lbe]], [[1r16|1r16]], [[3zwx|3zwx]], [[3zwm|3zwm]], [[3zwv|3zwv]], [[3zwy|3zwy]], [[3zwp|3zwp]], [[3zww|3zww]], [[1r15|1r15]], [[1r12|1r12]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G2Q:GUANOSINE+DIPHOSPHATE+RIBOSE'>G2Q</scene>, <scene name='pdbligand=NGD:3-(AMINOCARBONYL)-1-[(2R,3R,4S,5R)-5-({[(S)-{[(S)-{[(2R,3S,4R,5R)-5-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)-3,4-DIHYD+ROXYTETRAHYDROFURAN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]OXY}METHYL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-+YL]PYRIDINIUM'>NGD</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zwo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zwo OCA], [https://pdbe.org/3zwo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zwo RCSB], [https://www.ebi.ac.uk/pdbsum/3zwo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zwo ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zwo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zwo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zwo RCSB], [http://www.ebi.ac.uk/pdbsum/3zwo PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NADA_APLCA NADA_APLCA]] Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for calcium mobilization from endoplasmic reticulum. Also has cADPr hydrolase activity.<ref>PMID:11829748</ref>
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[https://www.uniprot.org/uniprot/NADA_APLCA NADA_APLCA] Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for calcium mobilization from endoplasmic reticulum. Also has cADPr hydrolase activity.<ref>PMID:11829748</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3zwo" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[ADP-ribosyl cyclase|ADP-ribosyl cyclase]]
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*[[Cluster of Differentiation CD38|Cluster of Differentiation CD38]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Aplysia californica]]
[[Category: Aplysia californica]]
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[[Category: Graeff, R]]
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[[Category: Large Structures]]
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[[Category: Hao, Q]]
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[[Category: Graeff R]]
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[[Category: Kotaka, M]]
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[[Category: Hao Q]]
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[[Category: Lee, H C]]
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[[Category: Kotaka M]]
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[[Category: Zhang, L H]]
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[[Category: Lee HC]]
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[[Category: Cd38]]
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[[Category: Zhang LH]]
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[[Category: Hydrolase]]
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[[Category: Hydrolysis]]
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[[Category: Nad]]
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[[Category: Substrate specificity]]
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Current revision

Crystal structure of ADP ribosyl cyclase complexed with reaction intermediate

PDB ID 3zwo

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