3h95

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==Crystal structure of the NUDIX domain of NUDT6==
==Crystal structure of the NUDIX domain of NUDT6==
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<StructureSection load='3h95' size='340' side='right' caption='[[3h95]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='3h95' size='340' side='right'caption='[[3h95]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3h95]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H95 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3H95 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3h95]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H95 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H95 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FGF2AS, NUDT6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h95 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3h95 RCSB], [http://www.ebi.ac.uk/pdbsum/3h95 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h95 OCA], [https://pdbe.org/3h95 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h95 RCSB], [https://www.ebi.ac.uk/pdbsum/3h95 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h95 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NUDT6_HUMAN NUDT6_HUMAN]] May contribute to the regulation of cell proliferation.<ref>PMID:11266510</ref> <ref>PMID:17569023</ref>
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[https://www.uniprot.org/uniprot/NUDT6_HUMAN NUDT6_HUMAN] May contribute to the regulation of cell proliferation.<ref>PMID:11266510</ref> <ref>PMID:17569023</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h9/3h95_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h9/3h95_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3h95 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
== References ==
== References ==
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H]]
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[[Category: Large Structures]]
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[[Category: Berg, S Van Den]]
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[[Category: Arrowsmith CH]]
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[[Category: Berglund, H]]
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[[Category: Berglund H]]
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[[Category: Bountra, C]]
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[[Category: Bountra C]]
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[[Category: Collins, R]]
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[[Category: Collins R]]
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[[Category: Edwards, A M]]
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[[Category: Edwards AM]]
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[[Category: Flodin, S]]
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[[Category: Flodin S]]
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[[Category: Flores, A]]
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[[Category: Flores A]]
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[[Category: Graslund, S]]
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[[Category: Graslund S]]
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[[Category: Hammarstrom, M]]
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[[Category: Hammarstrom M]]
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[[Category: Johansson, A]]
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[[Category: Johansson A]]
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[[Category: Johansson, I]]
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[[Category: Johansson I]]
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[[Category: Karlberg, T]]
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[[Category: Karlberg T]]
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[[Category: Kotyenova, T]]
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[[Category: Kotyenova T]]
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[[Category: Kotzch, A]]
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[[Category: Kotzch A]]
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[[Category: Moche, M]]
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[[Category: Moche M]]
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[[Category: Nielsen, T K]]
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[[Category: Nielsen TK]]
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[[Category: Nordlund, P]]
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[[Category: Nordlund P]]
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[[Category: Nyman, T]]
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[[Category: Nyman T]]
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[[Category: Persson, C]]
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[[Category: Persson C]]
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[[Category: Structural genomic]]
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[[Category: Sagemark J]]
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[[Category: Sagemark, J]]
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[[Category: Schueler H]]
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[[Category: Schueler, H]]
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[[Category: Schutz P]]
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[[Category: Schutz, P]]
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[[Category: Siponen MI]]
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[[Category: Siponen, M I]]
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[[Category: Svensson L]]
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[[Category: Svensson, L]]
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[[Category: Thorsell AG]]
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[[Category: Thorsell, A G]]
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[[Category: Tresaugues L]]
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[[Category: Tresaugues, L]]
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[[Category: Van Den Berg S]]
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[[Category: Weigelt, J]]
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[[Category: Weigelt J]]
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[[Category: Welin, M]]
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[[Category: Welin M]]
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[[Category: Wisniewska, M]]
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[[Category: Wisniewska M]]
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[[Category: Fgf2a]]
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[[Category: Gene regulation]]
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[[Category: Gfg]]
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[[Category: Gfg-1]]
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[[Category: Hydrolase]]
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[[Category: Isopeptide bond]]
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[[Category: Nudix]]
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[[Category: Nudt6]]
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[[Category: Sgc]]
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[[Category: Sgc stockholm]]
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Current revision

Crystal structure of the NUDIX domain of NUDT6

PDB ID 3h95

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