4j7z

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==Thermus thermophilus DNAJ J- and G/F-DOMAINS==
==Thermus thermophilus DNAJ J- and G/F-DOMAINS==
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<StructureSection load='4j7z' size='340' side='right' caption='[[4j7z]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
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<StructureSection load='4j7z' size='340' side='right'caption='[[4j7z]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4j7z]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus_hb8 Thermus thermophilus hb8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J7Z FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4j7z]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J7Z FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">EPR , Hybrid , X-ray diffraction, [[Resolution|Resolution]] 1.64&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4j80|4j80]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dnaJ2, TTHA1489 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 Thermus thermophilus HB8])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j7z OCA], [https://pdbe.org/4j7z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j7z RCSB], [https://www.ebi.ac.uk/pdbsum/4j7z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j7z ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j7z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j7z RCSB], [http://www.ebi.ac.uk/pdbsum/4j7z PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DNAJ2_THET8 DNAJ2_THET8]] Does not influence ATP binding or hydrolysis nor ADP release. Exerts influence on the interaction of DnaK with substrates; in the presence of DafA, DnaJ inhibits substrate binding, and substrate already bound to DnaK is displaced by DnaJ and DafA.<ref>PMID:10092456</ref>
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[https://www.uniprot.org/uniprot/DNAJ2_THET8 DNAJ2_THET8] Does not influence ATP binding or hydrolysis nor ADP release. Exerts influence on the interaction of DnaK with substrates; in the presence of DafA, DnaJ inhibits substrate binding, and substrate already bound to DnaK is displaced by DnaJ and DafA.<ref>PMID:10092456</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Hsp70 chaperones assist in a large variety of protein-folding processes in the cell. Crucial for these activities is the regulation of Hsp70 by Hsp40 cochaperones. DnaJ, the bacterial homologue of Hsp40, stimulates ATP hydrolysis by DnaK (Hsp70) and thus mediates capture of substrate protein, but is also known to possess chaperone activity of its own. The first structure of a complete functional dimeric DnaJ was determined and the mobility of its individual domains in solution was investigated. Crystal structures of the complete molecular cochaperone DnaJ from Thermus thermophilus comprising the J, GF and C-terminal domains and of the J and GF domains alone showed an ordered GF domain interacting with the J domain. Structure-based EPR spin-labelling studies as well as cross-linking results showed the existence of multiple states of DnaJ in solution with different arrangements of the various domains, which has implications for the function of DnaJ.
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Combining crystallography and EPR: crystal and solution structures of the multidomain cochaperone DnaJ.,Barends TR, Brosi RW, Steinmetz A, Scherer A, Hartmann E, Eschenbach J, Lorenz T, Seidel R, Shoeman RL, Zimmermann S, Bittl R, Schlichting I, Reinstein J Acta Crystallogr D Biol Crystallogr. 2013 Aug;69(Pt 8):1540-52. doi:, 10.1107/S0907444913010640. Epub 2013 Jul 19. PMID:23897477<ref>PMID:23897477</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==See Also==
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</div>
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Thermus thermophilus hb8]]
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[[Category: Large Structures]]
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[[Category: Barends, T R.M]]
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[[Category: Thermus thermophilus HB8]]
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[[Category: Bittl, R]]
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[[Category: Barends TRM]]
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[[Category: Brosi, R W]]
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[[Category: Bittl R]]
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[[Category: Eschenbach, J]]
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[[Category: Brosi RW]]
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[[Category: Hartmann, E]]
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[[Category: Eschenbach J]]
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[[Category: Lorenz, T]]
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[[Category: Hartmann E]]
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[[Category: Reinstein, J]]
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[[Category: Lorenz T]]
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[[Category: Scherer, A]]
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[[Category: Reinstein J]]
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[[Category: Schlichting, I]]
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[[Category: Scherer A]]
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[[Category: Seidel, R]]
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[[Category: Schlichting I]]
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[[Category: Shoeman, R]]
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[[Category: Seidel R]]
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[[Category: Steinmetz, A]]
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[[Category: Shoeman R]]
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[[Category: Zimmermann, S]]
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[[Category: Steinmetz A]]
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[[Category: Chaperone]]
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[[Category: Zimmermann S]]
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[[Category: Dna replication]]
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[[Category: J-domain]]
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[[Category: Polyproline-ii helix]]
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[[Category: Stress response]]
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Current revision

Thermus thermophilus DNAJ J- and G/F-DOMAINS

PDB ID 4j7z

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