4jbj
From Proteopedia
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==Structural mimicry for functional antagonism== | ==Structural mimicry for functional antagonism== | ||
| - | <StructureSection load='4jbj' size='340' side='right' caption='[[4jbj]], [[Resolution|resolution]] 2.69Å' scene=''> | + | <StructureSection load='4jbj' size='340' side='right'caption='[[4jbj]], [[Resolution|resolution]] 2.69Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4jbj]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4jbj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JBJ FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.692Å</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jbj OCA], [https://pdbe.org/4jbj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jbj RCSB], [https://www.ebi.ac.uk/pdbsum/4jbj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jbj ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/IFI2_MOUSE IFI2_MOUSE] Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Has anti-apoptotic effects due to inhibition of the transcriptional activity of p53. Binds dsDNA in the cytosol. Is involved in innate immune response and has anti-inflammatory activity. Inhibits caspase activation in response to cytosolic DNA and may inhibit the activation of the AIM2 inflammasome, probably via association with AIM2.<ref>PMID:16670293</ref> <ref>PMID:19131592</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Cheng | + | [[Category: Cheng G]] |
| - | [[Category: Ding | + | [[Category: Ding W]] |
| - | [[Category: Hung | + | [[Category: Hung L-W]] |
| - | [[Category: Liu | + | [[Category: Liu Z-J]] |
| - | [[Category: Ma | + | [[Category: Ma F]] |
| - | [[Category: Ni | + | [[Category: Ni X]] |
| - | [[Category: Ru | + | [[Category: Ru H]] |
| - | [[Category: Shaw | + | [[Category: Shaw N]] |
| - | [[Category: Zhao | + | [[Category: Zhao L]] |
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Current revision
Structural mimicry for functional antagonism
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Categories: Large Structures | Mus musculus | Cheng G | Ding W | Hung L-W | Liu Z-J | Ma F | Ni X | Ru H | Shaw N | Zhao L
