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1akp
From Proteopedia
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==SEQUENTIAL 1H,13C AND 15N NMR ASSIGNMENTS AND SOLUTION CONFORMATION OF APOKEDARCIDIN== | ==SEQUENTIAL 1H,13C AND 15N NMR ASSIGNMENTS AND SOLUTION CONFORMATION OF APOKEDARCIDIN== | ||
| - | <StructureSection load='1akp' size='340' side='right' caption='[[1akp | + | <StructureSection load='1akp' size='340' side='right'caption='[[1akp]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1akp]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1akp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Actinomycete_ATCC_53650 Actinomycete ATCC 53650]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AKP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AKP FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 15 models</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1akp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1akp OCA], [https://pdbe.org/1akp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1akp RCSB], [https://www.ebi.ac.uk/pdbsum/1akp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1akp ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/KEDA_ACTSL KEDA_ACTSL] Binds non-covalently to an enediyne chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore cleaves duplex DNA site-specifically in a single-stranded manner. The apoprotein cleaves proteins selectively, in particular highly basic histones, with H1 proteins being cleaved the more readily. |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 1akp" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Actinomycete | + | [[Category: Actinomycete ATCC 53650]] |
| - | [[Category: Bruccoleri | + | [[Category: Large Structures]] |
| - | [[Category: Colson | + | [[Category: Bruccoleri RE]] |
| - | [[Category: Constantine | + | [[Category: Colson KL]] |
| - | [[Category: | + | [[Category: Constantine KL]] |
| - | [[Category: | + | [[Category: Farmer II BT]] |
| - | [[Category: Lam | + | [[Category: Friedrichs MS]] |
| - | [[Category: Langley | + | [[Category: Lam KS]] |
| - | [[Category: Leet | + | [[Category: Langley DR]] |
| - | [[Category: Metzler | + | [[Category: Leet JE]] |
| - | [[Category: Mueller | + | [[Category: Metzler WJ]] |
| - | [[Category: Schroeder | + | [[Category: Mueller L]] |
| - | [[Category: Tuttle | + | [[Category: Schroeder DR]] |
| - | [[Category: Wittekind | + | [[Category: Tuttle J]] |
| - | [[Category: Zein | + | [[Category: Wittekind M]] |
| - | + | [[Category: Zein N]] | |
Current revision
SEQUENTIAL 1H,13C AND 15N NMR ASSIGNMENTS AND SOLUTION CONFORMATION OF APOKEDARCIDIN
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