4by9

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==The structure of the Box CD enzyme reveals regulation of rRNA methylation==
==The structure of the Box CD enzyme reveals regulation of rRNA methylation==
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<StructureSection load='4by9' size='340' side='right' caption='[[4by9]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
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<StructureSection load='4by9' size='340' side='right'caption='[[4by9]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4by9]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BY9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4by9]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BY9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BY9 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4by9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4by9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4by9 RCSB], [http://www.ebi.ac.uk/pdbsum/4by9 PDBsum]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4by9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4by9 OCA], [https://pdbe.org/4by9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4by9 RCSB], [https://www.ebi.ac.uk/pdbsum/4by9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4by9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FLPA_PYRFU FLPA_PYRFU]] Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity).[HAMAP-Rule:MF_00351] [[http://www.uniprot.org/uniprot/RL7A_PYRFU RL7A_PYRFU]] Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, box H/ACA, box C/D and box C'/D' sRNAs (By similarity).
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[https://www.uniprot.org/uniprot/Q8U4M1_PYRFU Q8U4M1_PYRFU]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4by9" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Pyrococcus furiosus]]
[[Category: Pyrococcus furiosus]]
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[[Category: Carlomagno, T]]
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[[Category: Carlomagno T]]
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[[Category: Gabel, F]]
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[[Category: Gabel F]]
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[[Category: Lapinaite, A]]
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[[Category: Lapinaite A]]
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[[Category: Rakwalska-Bange, M]]
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[[Category: Rakwalska-Bange M]]
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[[Category: Simon, B]]
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[[Category: Simon B]]
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[[Category: Skjaerven, L]]
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[[Category: Skjaerven L]]
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[[Category: Rrna modification]]
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[[Category: Transferase-rna complex]]
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Current revision

The structure of the Box CD enzyme reveals regulation of rRNA methylation

PDB ID 4by9

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