4wlb

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==Crystal structure of RORc in complex with a partial inverse agonist compound==
==Crystal structure of RORc in complex with a partial inverse agonist compound==
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<StructureSection load='4wlb' size='340' side='right' caption='[[4wlb]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='4wlb' size='340' side='right'caption='[[4wlb]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4wlb]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WLB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WLB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4wlb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WLB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WLB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3QQ:N-(4-FLUOROBENZYL)-N-(2-METHYLPROPYL)-6-{[1-(METHYLSULFONYL)PIPERIDIN-4-YL]AMINO}PYRIDINE-3-SULFONAMIDE'>3QQ</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.702&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wlb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wlb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wlb RCSB], [http://www.ebi.ac.uk/pdbsum/4wlb PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3QQ:N-(4-FLUOROBENZYL)-N-(2-METHYLPROPYL)-6-{[1-(METHYLSULFONYL)PIPERIDIN-4-YL]AMINO}PYRIDINE-3-SULFONAMIDE'>3QQ</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wlb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wlb OCA], [https://pdbe.org/4wlb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wlb RCSB], [https://www.ebi.ac.uk/pdbsum/4wlb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wlb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN]] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
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[https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4wlb" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Boenig, G]]
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[[Category: Homo sapiens]]
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[[Category: Hymowitz, S G]]
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[[Category: Large Structures]]
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[[Category: Kiefer, J R]]
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[[Category: Boenig G]]
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[[Category: Nuclear receptor ligand binding domain]]
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[[Category: Hymowitz SG]]
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[[Category: Transcription]]
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[[Category: Kiefer JR]]

Current revision

Crystal structure of RORc in complex with a partial inverse agonist compound

PDB ID 4wlb

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