4l8z

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==Crystal structure of Human Hsp90 with RL1==
==Crystal structure of Human Hsp90 with RL1==
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<StructureSection load='4l8z' size='340' side='right' caption='[[4l8z]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='4l8z' size='340' side='right'caption='[[4l8z]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4l8z]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L8Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L8Z FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4l8z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L8Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L8Z FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RL1:[5-(6-BROMO[1,2,4]TRIAZOLO[4,3-A]PYRIDIN-3-YL)-2,4-DIHYDROXYPHENYL](3,4-DIHYDROISOQUINOLIN-2(1H)-YL)METHANONE'>RL1</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.703&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4l90|4l90]], [[4l91|4l91]], [[4l93|4l93]], [[4l94|4l94]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RL1:[5-(6-BROMO[1,2,4]TRIAZOLO[4,3-A]PYRIDIN-3-YL)-2,4-DIHYDROXYPHENYL](3,4-DIHYDROISOQUINOLIN-2(1H)-YL)METHANONE'>RL1</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l8z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l8z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l8z RCSB], [http://www.ebi.ac.uk/pdbsum/4l8z PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l8z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l8z OCA], [https://pdbe.org/4l8z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l8z RCSB], [https://www.ebi.ac.uk/pdbsum/4l8z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l8z ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
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[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4l8z" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: He, J]]
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[[Category: Homo sapiens]]
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[[Category: Li, J]]
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[[Category: Large Structures]]
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[[Category: Ren, J]]
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[[Category: He J]]
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[[Category: Xiong, B]]
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[[Category: Li J]]
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[[Category: Yang, M]]
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[[Category: Ren J]]
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[[Category: Atp hydrolysis]]
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[[Category: Xiong B]]
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[[Category: Chaperone-chaperone inhibitor complex]]
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[[Category: Yang M]]
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[[Category: Hsp90n-hsp90n inhibitor complex]]
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Current revision

Crystal structure of Human Hsp90 with RL1

PDB ID 4l8z

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