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2ajp

From Proteopedia

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[[Image:2ajp.gif|left|200px]]
 
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{{Structure
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==Crystal structure of a human pyridoxal kinase==
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|PDB= 2ajp |SIZE=350|CAPTION= <scene name='initialview01'>2ajp</scene>, resolution 2.500&Aring;
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<StructureSection load='2ajp' size='340' side='right'caption='[[2ajp]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene> and <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER'>ANP</scene>
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<table><tr><td colspan='2'>[[2ajp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AJP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AJP FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Pyridoxal_kinase Pyridoxal kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.35 2.7.1.35]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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|GENE= PDXK, PKH, PNK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ajp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ajp OCA], [https://pdbe.org/2ajp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ajp RCSB], [https://www.ebi.ac.uk/pdbsum/2ajp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ajp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDXK_HUMAN PDXK_HUMAN] Required for synthesis of pyridoxal-5-phosphate from vitamin B6.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aj/2ajp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ajp ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of a human pyridoxal kinase'''
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==See Also==
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*[[Pyridoxal kinase|Pyridoxal kinase]]
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__TOC__
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==Disease==
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</StructureSection>
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Known diseases associated with this structure: Paroxysmal nonkinesigenic dyskinesia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=609023 609023]], Polycystic kidney and hepatic disease OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=606702 606702]]
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==About this Structure==
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2AJP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AJP OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Pyridoxal kinase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Arrowsmith C]]
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[[Category: Arrowsmith, C.]]
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[[Category: Atanassova A]]
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[[Category: Atanassova, A.]]
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[[Category: Bochkarev A]]
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[[Category: Bochkarev, A.]]
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[[Category: Dimov S]]
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[[Category: Dimov, S.]]
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[[Category: Edwards A]]
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[[Category: Edwards, A.]]
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[[Category: Ismail S]]
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[[Category: Ismail, S.]]
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[[Category: Park H]]
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[[Category: Park, H.]]
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[[Category: Sundstrom M]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Tempel W]]
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[[Category: Sundstrom, M.]]
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[[Category: Weigelt J]]
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[[Category: Tempel, W.]]
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[[Category: Weigelt, J.]]
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[[Category: ANP]]
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[[Category: MG]]
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[[Category: UNX]]
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[[Category: pyridoxal kinase]]
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[[Category: sgc]]
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[[Category: structural genomic]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:50:30 2008''
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Current revision

Crystal structure of a human pyridoxal kinase

PDB ID 2ajp

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