3zbd

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==Structure of TGEV nsp1==
==Structure of TGEV nsp1==
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<StructureSection load='3zbd' size='340' side='right' caption='[[3zbd]], [[Resolution|resolution]] 1.49&Aring;' scene=''>
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<StructureSection load='3zbd' size='340' side='right'caption='[[3zbd]], [[Resolution|resolution]] 1.49&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3zbd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Porcine_transmissible_gastroenteritis_coronavirus_strain_purdue Porcine transmissible gastroenteritis coronavirus strain purdue]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZBD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZBD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3zbd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Porcine_transmissible_gastroenteritis_coronavirus_strain_Purdue Porcine transmissible gastroenteritis coronavirus strain Purdue]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZBD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZBD FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zbd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zbd RCSB], [http://www.ebi.ac.uk/pdbsum/3zbd PDBsum]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.49&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zbd OCA], [https://pdbe.org/3zbd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zbd RCSB], [https://www.ebi.ac.uk/pdbsum/3zbd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zbd ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/R1A_CVPPU R1A_CVPPU]] The papain-like proteinase 1 (PLP1) and papain-like proteinase 2 (PLP2) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. PLP2 also antagonizes innate immune induction of type I interferon by blocking the nuclear translocation of host IRF-3 (By similarity). The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SAGC]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter (By similarity). Nsp9 is a ssRNA-binding protein (By similarity).
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[https://www.uniprot.org/uniprot/R1A_CVPPU R1A_CVPPU] The papain-like proteinase 1 (PLP1) and papain-like proteinase 2 (PLP2) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. PLP2 also antagonizes innate immune induction of type I interferon by blocking the nuclear translocation of host IRF-3 (By similarity). The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SAGC]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter (By similarity). Nsp9 is a ssRNA-binding protein (By similarity).
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3zbd" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Porcine transmissible gastroenteritis coronavirus strain purdue]]
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[[Category: Large Structures]]
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[[Category: Jansson, A M]]
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[[Category: Porcine transmissible gastroenteritis coronavirus strain Purdue]]
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[[Category: Alphacoronavirus]]
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[[Category: Jansson AM]]
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[[Category: Coronavirus]]
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[[Category: Nsp1]]
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[[Category: Viral protein]]
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Current revision

Structure of TGEV nsp1

PDB ID 3zbd

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