3uk3
From Proteopedia
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==Crystal structure of ZNF217 bound to DNA== | ==Crystal structure of ZNF217 bound to DNA== | ||
| - | <StructureSection load='3uk3' size='340' side='right' caption='[[3uk3]], [[Resolution|resolution]] 2.10Å' scene=''> | + | <StructureSection load='3uk3' size='340' side='right'caption='[[3uk3]], [[Resolution|resolution]] 2.10Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3uk3]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3uk3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UK3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UK3 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uk3 OCA], [https://pdbe.org/3uk3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uk3 RCSB], [https://www.ebi.ac.uk/pdbsum/3uk3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uk3 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/ZN217_HUMAN ZN217_HUMAN] Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'.<ref>PMID:16203743</ref> <ref>PMID:17259635</ref> <ref>PMID:18625718</ref> <ref>PMID:16940172</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Guss JM]] |
| - | [[Category: | + | [[Category: Jacques DA]] |
| - | [[Category: | + | [[Category: Mackay JP]] |
| - | [[Category: | + | [[Category: Vandevenne MS]] |
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Current revision
Crystal structure of ZNF217 bound to DNA
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