4wh9

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==Structure of the CDC25B Phosphatase Catalytic Domain with Bound Inhibitor==
==Structure of the CDC25B Phosphatase Catalytic Domain with Bound Inhibitor==
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<StructureSection load='4wh9' size='340' side='right' caption='[[4wh9]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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<StructureSection load='4wh9' size='340' side='right'caption='[[4wh9]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4wh9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WH9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WH9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4wh9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WH9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WH9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3M8:2-[(2-CYANO-3-FLUORO-5-HYDROXYPHENYL)SULFANYL]ETHANESULFONIC+ACID'>3M8</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wh7|4wh7]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3M8:2-[(2-CYANO-3-FLUORO-5-HYDROXYPHENYL)SULFANYL]ETHANESULFONIC+ACID'>3M8</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wh9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wh9 OCA], [https://pdbe.org/4wh9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wh9 RCSB], [https://www.ebi.ac.uk/pdbsum/4wh9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wh9 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wh9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wh9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wh9 RCSB], [http://www.ebi.ac.uk/pdbsum/4wh9 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MPIP2_HUMAN MPIP2_HUMAN]] Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.<ref>PMID:17332740</ref>
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[https://www.uniprot.org/uniprot/MPIP2_HUMAN MPIP2_HUMAN] Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.<ref>PMID:17332740</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4wh9" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]]
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*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Protein-tyrosine-phosphatase]]
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[[Category: Homo sapiens]]
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[[Category: Borkin, D]]
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[[Category: Large Structures]]
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[[Category: Cierpicki, T]]
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[[Category: Borkin D]]
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[[Category: Dudkin, S]]
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[[Category: Cierpicki T]]
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[[Category: Grembecka, J]]
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[[Category: Dudkin S]]
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[[Category: Lund, G L]]
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[[Category: Grembecka J]]
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[[Category: Ni, W]]
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[[Category: Lund GL]]
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[[Category: Fragment]]
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[[Category: Ni W]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Inhibitor]]
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[[Category: Phosphatase]]
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Current revision

Structure of the CDC25B Phosphatase Catalytic Domain with Bound Inhibitor

PDB ID 4wh9

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