2axv

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[[Image:2axv.gif|left|200px]]
 
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{{Structure
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==Structure of PrgX Y153C mutant==
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|PDB= 2axv |SIZE=350|CAPTION= <scene name='initialview01'>2axv</scene>, resolution 3.00&Aring;
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<StructureSection load='2axv' size='340' side='right'caption='[[2axv]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2axv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AXV FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2axv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2axv OCA], [https://pdbe.org/2axv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2axv RCSB], [https://www.ebi.ac.uk/pdbsum/2axv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2axv ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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'''Structure of PrgX Y153C mutant'''
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[https://www.uniprot.org/uniprot/Q04114_ENTFL Q04114_ENTFL]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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Many bacterial activities, including expression of virulence factors, horizontal genetic transfer, and production of antibiotics, are controlled by intercellular signaling using small molecules. To date, understanding of the molecular mechanisms of peptide-mediated cell-cell signaling has been limited by a dearth of published information about the molecular structures of the signaling components. Here, we present the molecular structure of PrgX, a DNA- and peptide-binding protein that regulates expression of the conjugative transfer genes of the Enterococcus faecalis plasmid pCF10 in response to an intercellular peptide pheromone signal. Comparison of the structures of PrgX and the PrgX/pheromone complex suggests that pheromone binding destabilizes PrgX tetramers, opening a 70-bp pCF10 DNA loop required for conjugation repression.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ax/2axv_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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2AXV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXV OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2axv ConSurf].
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Structure of peptide sex pheromone receptor PrgX and PrgX/pheromone complexes and regulation of conjugation in Enterococcus faecalis., Shi K, Brown CK, Gu ZY, Kozlowicz BK, Dunny GM, Ohlendorf DH, Earhart CA, Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18596-601. Epub 2005 Dec 8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16339309 16339309]
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Enterococcus faecalis]]
[[Category: Enterococcus faecalis]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Brown, C K.]]
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[[Category: Brown CK]]
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[[Category: Dunny, G M.]]
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[[Category: Dunny GM]]
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[[Category: Earhart, C A.]]
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[[Category: Earhart CA]]
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[[Category: Gu, Z Y.]]
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[[Category: Gu ZY]]
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[[Category: Kozlowicz, B K.]]
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[[Category: Kozlowicz BK]]
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[[Category: Ohlendorf, D H.]]
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[[Category: Ohlendorf DH]]
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[[Category: Shi, K.]]
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[[Category: Shi K]]
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[[Category: dna binding]]
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[[Category: domain]]
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[[Category: pheromone]]
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[[Category: repressor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:55:13 2008''
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Current revision

Structure of PrgX Y153C mutant

PDB ID 2axv

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