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2az2

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[[Image:2az2.gif|left|200px]]
 
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{{Structure
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==Flock House virus B2-dsRNA Complex (P4122)==
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|PDB= 2az2 |SIZE=350|CAPTION= <scene name='initialview01'>2az2</scene>, resolution 2.60&Aring;
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<StructureSection load='2az2' size='340' side='right'caption='[[2az2]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2az2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Flock_House_virus Flock House virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AZ2 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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|GENE= B2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=12287 Flock house virus])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5BU:5-BROMO-URIDINE-5-MONOPHOSPHATE'>5BU</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2az2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2az2 OCA], [https://pdbe.org/2az2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2az2 RCSB], [https://www.ebi.ac.uk/pdbsum/2az2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2az2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/B2_FHV B2_FHV] Binds double-strand RNA (dsRNA) with high affinity. Suppresses the host RNA silencing-based antiviral response.<ref>PMID:14745017</ref> <ref>PMID:16228003</ref>
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'''Flock House virus B2-dsRNA Complex (P4122)'''
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==See Also==
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*[[Flock house virus protein B2|Flock house virus protein B2]]
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== References ==
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==Overview==
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<references/>
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As a counter-defense against antiviral RNA silencing during infection, the insect Flock House virus (FHV) expresses the silencing suppressor protein B2. Biochemical experiments show that B2 binds to double-stranded RNA (dsRNA) without regard to length and inhibits cleavage of dsRNA by Dicer in vitro. A cocrystal structure reveals that a B2 dimer forms a four-helix bundle that binds to one face of an A-form RNA duplex independently of sequence. These results suggest that B2 blocks both cleavage of the FHV genome by Dicer and incorporation of FHV small interfering RNAs into the RNA-induced silencing complex.
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Flock House virus]]
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2AZ2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Flock_house_virus Flock house virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZ2 OCA].
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[[Category: Large Structures]]
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[[Category: Chao JA]]
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==Reference==
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[[Category: Chapados BR]]
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Dual modes of RNA-silencing suppression by Flock House virus protein B2., Chao JA, Lee JH, Chapados BR, Debler EW, Schneemann A, Williamson JR, Nat Struct Mol Biol. 2005 Nov;12(11):952-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16228003 16228003]
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[[Category: Debler EW]]
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[[Category: Flock house virus]]
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[[Category: Lee JH]]
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[[Category: Single protein]]
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[[Category: Schneemann A]]
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[[Category: Chao, J A.]]
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[[Category: Williamson JR]]
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[[Category: Chapados, B R.]]
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[[Category: Debler, E W.]]
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[[Category: Lee, J H.]]
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[[Category: Schneemann, A.]]
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[[Category: Williamson, J R.]]
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[[Category: four-helix bundle]]
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[[Category: protein-rna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:55:35 2008''
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Current revision

Flock House virus B2-dsRNA Complex (P4122)

PDB ID 2az2

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