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4w8i
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==Crystal structure of LpSPL/Lpp2128, Legionella pneumophila sphingosine-1 phosphate lyase== | ==Crystal structure of LpSPL/Lpp2128, Legionella pneumophila sphingosine-1 phosphate lyase== | ||
| - | <StructureSection load='4w8i' size='340' side='right' caption='[[4w8i]], [[Resolution|resolution]] 2.85Å' scene=''> | + | <StructureSection load='4w8i' size='340' side='right'caption='[[4w8i]], [[Resolution|resolution]] 2.85Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4w8i]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W8I OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4w8i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila_str._Paris Legionella pneumophila str. Paris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W8I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4W8I FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4w8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w8i OCA], [https://pdbe.org/4w8i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4w8i RCSB], [https://www.ebi.ac.uk/pdbsum/4w8i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4w8i ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/SGPL_LEGPA SGPL_LEGPA] Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine (By similarity). Possibly implicated in influencing the macrophage autophagy pathway. |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Legionella pneumophila str. Paris]] |
| - | [[Category: | + | [[Category: Cuff M]] |
| - | [[Category: | + | [[Category: Daniels C]] |
| - | [[Category: Leo | + | [[Category: Di Leo R]] |
| - | [[Category: | + | [[Category: Joachimiak A]] |
| - | [[Category: Savchenko | + | [[Category: Savchenko A]] |
| - | [[Category: Skarina | + | [[Category: Skarina T]] |
| - | [[Category: Stogios | + | [[Category: Stogios PJ]] |
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Current revision
Crystal structure of LpSPL/Lpp2128, Legionella pneumophila sphingosine-1 phosphate lyase
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