3p1x

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==Crystal structure of DRBM 2 domain of Interleukin enhancer-binding factor 3 from Homo sapiens, Northeast Structural Genomics Consortium Target HR4527E==
==Crystal structure of DRBM 2 domain of Interleukin enhancer-binding factor 3 from Homo sapiens, Northeast Structural Genomics Consortium Target HR4527E==
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<StructureSection load='3p1x' size='340' side='right' caption='[[3p1x]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='3p1x' size='340' side='right'caption='[[3p1x]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3p1x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P1X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P1X FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3p1x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P1X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P1X FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p1x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p1x RCSB], [http://www.ebi.ac.uk/pdbsum/3p1x PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p1x OCA], [https://pdbe.org/3p1x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p1x RCSB], [https://www.ebi.ac.uk/pdbsum/3p1x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p1x ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ILF3_HUMAN ILF3_HUMAN]] May facilitate double-stranded RNA-regulated gene expression at the level of post-transcription. Can act as a translation inhibitory protein which binds to coding sequences of acid beta-glucosidase (GCase) and other mRNAs and functions at the initiation phase of GCase mRNA translation, probably by inhibiting its binding to polysomes. Can regulate protein arginine N-methyltransferase 1 activity. May regulate transcription of the IL2 gene during T-cell activation. Can promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. The phosphorylated form at Thr-188 and Thr-315, in concert with EIF2AK2/PKR can inhibit vesicular stomatitis virus (VSV) replication (By similarity).<ref>PMID:7519613</ref> <ref>PMID:9442054</ref>
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[https://www.uniprot.org/uniprot/ILF3_HUMAN ILF3_HUMAN] May facilitate double-stranded RNA-regulated gene expression at the level of post-transcription. Can act as a translation inhibitory protein which binds to coding sequences of acid beta-glucosidase (GCase) and other mRNAs and functions at the initiation phase of GCase mRNA translation, probably by inhibiting its binding to polysomes. Can regulate protein arginine N-methyltransferase 1 activity. May regulate transcription of the IL2 gene during T-cell activation. Can promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. The phosphorylated form at Thr-188 and Thr-315, in concert with EIF2AK2/PKR can inhibit vesicular stomatitis virus (VSV) replication (By similarity).<ref>PMID:7519613</ref> <ref>PMID:9442054</ref>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Acton, T B]]
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[[Category: Large Structures]]
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[[Category: Baran, M C]]
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[[Category: Acton TB]]
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[[Category: Cunningham, K]]
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[[Category: Baran MC]]
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[[Category: Hunt, J F]]
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[[Category: Cunningham K]]
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[[Category: Janjua, H]]
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[[Category: Hunt JF]]
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[[Category: Liu, J]]
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[[Category: Janjua H]]
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[[Category: Montelione, G T]]
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[[Category: Liu J]]
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[[Category: Structural genomic]]
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[[Category: Montelione GT]]
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[[Category: Neely, H]]
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[[Category: Neely H]]
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[[Category: Owens, L]]
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[[Category: Owens L]]
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[[Category: Seetharaman, J]]
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[[Category: Seetharaman J]]
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[[Category: Tong, L]]
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[[Category: Tong L]]
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[[Category: Wang, D]]
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[[Category: Wang D]]
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[[Category: Xiao, R]]
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[[Category: Xiao R]]
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[[Category: Nesg]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Psi-biology]]
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[[Category: Transcription regulator]]
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Current revision

Crystal structure of DRBM 2 domain of Interleukin enhancer-binding factor 3 from Homo sapiens, Northeast Structural Genomics Consortium Target HR4527E

PDB ID 3p1x

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