This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4c2i

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:07, 9 May 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Cryo-EM structure of Dengue virus serotype 1 complexed with Fab fragments of human antibody 1F4==
==Cryo-EM structure of Dengue virus serotype 1 complexed with Fab fragments of human antibody 1F4==
-
<StructureSection load='4c2i' size='340' side='right' caption='[[4c2i]], [[Resolution|resolution]] 6.00&Aring;' scene=''>
+
<SX load='4c2i' size='340' side='right' viewer='molstar' caption='[[4c2i]], [[Resolution|resolution]] 6.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4c2i]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_1 Dengue virus 1] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C2I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C2I FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4c2i]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_1 Dengue virus 1] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C2I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C2I FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6&#8491;</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c2i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c2i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c2i RCSB], [http://www.ebi.ac.uk/pdbsum/4c2i PDBsum]</span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900017:triacetyl-beta-chitotriose'>PRD_900017</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c2i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c2i OCA], [https://pdbe.org/4c2i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c2i RCSB], [https://www.ebi.ac.uk/pdbsum/4c2i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c2i ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/Q7TGE4_9FLAV Q7TGE4_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS027287_004_099774] [[http://www.uniprot.org/uniprot/G3F5K5_9FLAV G3F5K5_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]
+
[https://www.uniprot.org/uniprot/Q7TGE4_9FLAV Q7TGE4_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS027287_004_099774]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 16: Line 18:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 4c2i" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
-
*[[Antibody|Antibody]]
+
*[[Antibody 3D structures|Antibody 3D structures]]
 +
*[[3D structures of human antibody|3D structures of human antibody]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
-
</StructureSection>
+
</SX>
[[Category: Dengue virus 1]]
[[Category: Dengue virus 1]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Alwis, R de]]
+
[[Category: Large Structures]]
-
[[Category: Fibriansah, G]]
+
[[Category: Crowe Junior JE]]
-
[[Category: Harris, E]]
+
[[Category: Fibriansah G]]
-
[[Category: Ibarra, K D]]
+
[[Category: Harris E]]
-
[[Category: Junior, J E.Crowe]]
+
[[Category: Ibarra KD]]
-
[[Category: Kostyuchenko, V A]]
+
[[Category: Kostyuchenko VA]]
-
[[Category: Lok, S M]]
+
[[Category: Lok S-M]]
-
[[Category: Ng, T S]]
+
[[Category: Ng T-S]]
-
[[Category: Silva, A de]]
+
[[Category: Smith SA]]
-
[[Category: Smith, S A]]
+
[[Category: Tan JL]]
-
[[Category: Tan, J L]]
+
[[Category: De Alwis R]]
-
[[Category: E protein]]
+
[[Category: De Silva A]]
-
[[Category: Neutralization]]
+
-
[[Category: Virus]]
+

Current revision

Cryo-EM structure of Dengue virus serotype 1 complexed with Fab fragments of human antibody 1F4

4c2i, resolution 6.00Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4c2i"
Personal tools