2c4b

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==INHIBITOR CYSTINE KNOT PROTEIN MCOEETI FUSED TO THE CATALYTICALLY INACTIVE BARNASE MUTANT H102A==
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<StructureSection load='2c4b' size='340' side='right' caption='[[2c4b]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
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==Inhibitor cystine knot protein McoEeTI fused to the catalytically inactive barnase mutant H102A==
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<StructureSection load='2c4b' size='340' side='right'caption='[[2c4b]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2c4b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_amyloliquefaciens Bacillus amyloliquefaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C4B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C4B FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2c4b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_amyloliquefaciens Bacillus amyloliquefaciens], [https://en.wikipedia.org/wiki/Ecballium_elaterium Ecballium elaterium] and [https://en.wikipedia.org/wiki/Momordica_cochinchinensis Momordica cochinchinensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C4B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C4B FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2PE:NONAETHYLENE+GLYCOL'>2PE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a2p|1a2p]], [[1b20|1b20]], [[1b21|1b21]], [[1b27|1b27]], [[1b2s|1b2s]], [[1b2u|1b2u]], [[1b2x|1b2x]], [[1b2z|1b2z]], [[1b3s|1b3s]], [[1ban|1ban]], [[1bao|1bao]], [[1bgs|1bgs]], [[1bne|1bne]], [[1bnf|1bnf]], [[1bng|1bng]], [[1bni|1bni]], [[1bnj|1bnj]], [[1bnr|1bnr]], [[1bns|1bns]], [[1brg|1brg]], [[1brh|1brh]], [[1bri|1bri]], [[1brj|1brj]], [[1brk|1brk]], [[1brn|1brn]], [[1brs|1brs]], [[1bsa|1bsa]], [[1bsb|1bsb]], [[1bsc|1bsc]], [[1bsd|1bsd]], [[1bse|1bse]], [[1fw7|1fw7]], [[1h9h|1h9h]], [[1h9i|1h9i]], [[1ha9|1ha9]], [[1ib9|1ib9]], [[1rnb|1rnb]], [[1w7z|1w7z]], [[1x1u|1x1u]], [[1x1w|1x1w]], [[1x1x|1x1x]], [[1x1y|1x1y]], [[1yvs|1yvs]], [[2eti|2eti]], [[2let|2let]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2PE:NONAETHYLENE+GLYCOL'>2PE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_T(1) Ribonuclease T(1)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.3 3.1.27.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c4b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c4b OCA], [https://pdbe.org/2c4b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c4b RCSB], [https://www.ebi.ac.uk/pdbsum/2c4b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c4b ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c4b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c4b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c4b RCSB], [http://www.ebi.ac.uk/pdbsum/2c4b PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RNBR_BACAM RNBR_BACAM]] Hydrolyzes phosphodiester bonds in RNA, poly- and oligoribonucleotides resulting in 3'-nucleoside monophosphates via 2',3'-cyclophosphate intermediates.
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[https://www.uniprot.org/uniprot/RNBR_BACAM RNBR_BACAM] Hydrolyzes phosphodiester bonds in RNA, poly- and oligoribonucleotides resulting in 3'-nucleoside monophosphates via 2',3'-cyclophosphate intermediates.[https://www.uniprot.org/uniprot/ITR2_ECBEL ITR2_ECBEL] Inhibits trypsin.[https://www.uniprot.org/uniprot/ITR2_MOMCO ITR2_MOMCO]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c4/2c4b_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c4/2c4b_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c4b ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2c4b" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Barnase|Barnase]]
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*[[Barnase 3D structures|Barnase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Bacillus amyloliquefaciens]]
[[Category: Bacillus amyloliquefaciens]]
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[[Category: Heinz, D W]]
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[[Category: Ecballium elaterium]]
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[[Category: Kolmar, H]]
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[[Category: Large Structures]]
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[[Category: Niemann, H H]]
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[[Category: Momordica cochinchinensis]]
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[[Category: Schmoldt, H U]]
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[[Category: Heinz DW]]
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[[Category: Wentzel, A]]
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[[Category: Kolmar H]]
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[[Category: Endonuclease]]
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[[Category: Niemann HH]]
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[[Category: Fusion protein]]
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[[Category: Schmoldt HU]]
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[[Category: Hybrid microprotein]]
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[[Category: Wentzel A]]
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[[Category: Hydrolase]]
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[[Category: Nuclease]]
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[[Category: Protease inhibitor]]
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[[Category: Ribonuclease]]
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[[Category: Serine protease inhibitor]]
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[[Category: Squash inhibitor]]
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Current revision

Inhibitor cystine knot protein McoEeTI fused to the catalytically inactive barnase mutant H102A

PDB ID 2c4b

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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