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3sa1
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==Bacuills anthracis Dihydrofolate Reductase bound propargyl-linked TMP analog, UCP1021== | ==Bacuills anthracis Dihydrofolate Reductase bound propargyl-linked TMP analog, UCP1021== | ||
| - | <StructureSection load='3sa1' size='340' side='right' caption='[[3sa1]], [[Resolution|resolution]] 2.50Å' scene=''> | + | <StructureSection load='3sa1' size='340' side='right'caption='[[3sa1]], [[Resolution|resolution]] 2.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3sa1]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3sa1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SA1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SA1 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6DR:6-ETHYL-5-{3-[2-METHOXY-5-(PYRIDIN-4-YL)PHENYL]PROP-1-YN-1-YL}PYRIMIDINE-2,4-DIAMINE'>6DR</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6DR:6-ETHYL-5-{3-[2-METHOXY-5-(PYRIDIN-4-YL)PHENYL]PROP-1-YN-1-YL}PYRIMIDINE-2,4-DIAMINE'>6DR</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sa1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sa1 OCA], [https://pdbe.org/3sa1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sa1 RCSB], [https://www.ebi.ac.uk/pdbsum/3sa1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sa1 ProSAT]</span></td></tr> | |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/Q81R22_BACAN Q81R22_BACAN] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194] |
==See Also== | ==See Also== | ||
| - | *[[Dihydrofolate reductase|Dihydrofolate reductase]] | + | *[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]] |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Bacillus anthracis]] | [[Category: Bacillus anthracis]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Anderson | + | [[Category: Anderson AC]] |
| - | [[Category: Beierlein | + | [[Category: Beierlein JM]] |
| - | + | ||
Current revision
Bacuills anthracis Dihydrofolate Reductase bound propargyl-linked TMP analog, UCP1021
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