1xi3

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==Thiamine phosphate pyrophosphorylase from Pyrococcus furiosus Pfu-1255191-001==
==Thiamine phosphate pyrophosphorylase from Pyrococcus furiosus Pfu-1255191-001==
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<StructureSection load='1xi3' size='340' side='right' caption='[[1xi3]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='1xi3' size='340' side='right'caption='[[1xi3]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1xi3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XI3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XI3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1xi3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XI3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XI3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">thiE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2261 Pyrococcus furiosus])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiamine-phosphate_diphosphorylase Thiamine-phosphate diphosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.3 2.5.1.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xi3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xi3 OCA], [https://pdbe.org/1xi3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xi3 RCSB], [https://www.ebi.ac.uk/pdbsum/1xi3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xi3 ProSAT], [https://www.topsan.org/Proteins/SECSG/1xi3 TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xi3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xi3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xi3 RCSB], [http://www.ebi.ac.uk/pdbsum/1xi3 PDBsum], [http://www.topsan.org/Proteins/SECSG/1xi3 TOPSAN]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/THIE_PYRFU THIE_PYRFU]] Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity).
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[https://www.uniprot.org/uniprot/THIE_PYRFU THIE_PYRFU] Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xi/1xi3_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xi/1xi3_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xi3 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
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==See Also==
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*[[Thiamin phosphate synthase|Thiamin phosphate synthase]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Pyrococcus furiosus]]
[[Category: Pyrococcus furiosus]]
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[[Category: Thiamine-phosphate diphosphorylase]]
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[[Category: Adams MWW]]
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[[Category: Adams, M W.W]]
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[[Category: Arendall III WB]]
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[[Category: Chang, S H]]
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[[Category: Chang S-H]]
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[[Category: Chen, L]]
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[[Category: Chen L]]
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[[Category: Dillard, B D]]
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[[Category: Dillard BD]]
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[[Category: Eneh, J C]]
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[[Category: Eneh JC]]
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[[Category: Habel, J]]
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[[Category: Habel J]]
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[[Category: Hopkins, R C]]
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[[Category: Hopkins RC]]
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[[Category: II, F L.Poole]]
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[[Category: Jenney Jr FE]]
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[[Category: III, W B.Arendall]]
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[[Category: Kelley L-LC]]
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[[Category: Jenney, F E]]
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[[Category: Lee D]]
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[[Category: Kelley, L L.C]]
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[[Category: Lee H-S]]
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[[Category: Lee, D]]
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[[Category: Li T]]
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[[Category: Lee, H S]]
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[[Category: Lin D]]
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[[Category: Li, T]]
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[[Category: Liu Z-J]]
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[[Category: Lin, D]]
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[[Category: Poole II FL]]
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[[Category: Liu, Z J]]
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[[Category: Richardson DC]]
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[[Category: Richardson, D C]]
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[[Category: Richardson JS]]
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[[Category: Richardson, J S]]
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[[Category: Rose JP]]
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[[Category: Rose, J P]]
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[[Category: Shah C]]
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[[Category: Structural genomic]]
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[[Category: Sugar FJ]]
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[[Category: Shah, C]]
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[[Category: Tempel W]]
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[[Category: Sugar, F J]]
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[[Category: Wang B-C]]
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[[Category: Tempel, W]]
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[[Category: Zhou W]]
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[[Category: Wang, B C]]
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[[Category: Zhou, W]]
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[[Category: Hyperthermophile]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Secsg]]
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[[Category: Thiamine phosphate pyrophosphorylase]]
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[[Category: Transferase]]
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Current revision

Thiamine phosphate pyrophosphorylase from Pyrococcus furiosus Pfu-1255191-001

PDB ID 1xi3

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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