2bkw

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[[Image:2bkw.gif|left|200px]]
 
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{{Structure
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==Yeast alanine:glyoxylate aminotransferase YFL030w==
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|PDB= 2bkw |SIZE=350|CAPTION= <scene name='initialview01'>2bkw</scene>, resolution 2.57&Aring;
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<StructureSection load='2bkw' size='340' side='right'caption='[[2bkw]], [[Resolution|resolution]] 2.57&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Glv+Binding+Site+For+Chain+A'>AC1</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=GLV:GLYOXYLIC ACID'>GLV</scene>
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<table><tr><td colspan='2'>[[2bkw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BKW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BKW FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Alanine--glyoxylate_transaminase Alanine--glyoxylate transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.44 2.6.1.44]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.57&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLV:GLYOXYLIC+ACID'>GLV</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bkw OCA], [https://pdbe.org/2bkw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bkw RCSB], [https://www.ebi.ac.uk/pdbsum/2bkw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bkw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AGX1_YEAST AGX1_YEAST] Has alanine:glyoxylate aminotransferase activity.<ref>PMID:3933486</ref> <ref>PMID:16226833</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bk/2bkw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bkw ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We have determined the three-dimensional crystal structure of the protein encoded by the open reading frame YFL030w from Saccharomyces cerevisiae to a resolution of 2.6 A using single wavelength anomalous diffraction. YFL030w is a 385 amino-acid protein with sequence similarity to the aminotransferase family. The structure of the protein reveals a homodimer adopting the fold-type I of pyridoxal 5'-phosphate (PLP)-dependent aminotransferases. The PLP co-factor is covalently bound to the active site in the crystal structure. The protein shows close structural resemblance with the human alanine:glyoxylate aminotransferase (EC 2.6.1.44), an enzyme involved in the hereditary kidney stone disease primary hyperoxaluria type 1. In this paper we show that YFL030w codes for an alanine:glyoxylate aminotransferase, highly specific for its amino donor and acceptor substrates.
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'''YEAST ALANINE:GLYOXYLATE AMINOTRANSFERASE YFL030W'''
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Crystal structure and confirmation of the alanine:glyoxylate aminotransferase activity of the YFL030w yeast protein.,Meyer P, Liger D, Leulliot N, Quevillon-Cheruel S, Zhou CZ, Borel F, Ferrer JL, Poupon A, Janin J, van Tilbeurgh H Biochimie. 2005 Dec;87(12):1041-7. Epub 2005 Oct 5. PMID:16226833<ref>PMID:16226833</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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2BKW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BKW OCA].
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<div class="pdbe-citations 2bkw" style="background-color:#fffaf0;"></div>
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[[Category: Alanine--glyoxylate transaminase]]
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== References ==
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[[Category: Saccharomyces cerevisiae]]
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<references/>
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[[Category: Single protein]]
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__TOC__
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[[Category: Borel, F.]]
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</StructureSection>
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[[Category: Ferrer, J L.]]
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[[Category: Large Structures]]
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[[Category: Janin, J.]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Leulliot, N.]]
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[[Category: Borel F]]
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[[Category: Liger, D.]]
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[[Category: Ferrer JL]]
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[[Category: Meyer, P.]]
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[[Category: Janin J]]
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[[Category: Poupon, A.]]
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[[Category: Leulliot N]]
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[[Category: Quevillon-Cheruel, S.]]
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[[Category: Liger D]]
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[[Category: Tilbeurgh, H Van.]]
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[[Category: Meyer P]]
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[[Category: Zhou, C Z.]]
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[[Category: Poupon A]]
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[[Category: GLV]]
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[[Category: Quevillon-Cheruel S]]
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[[Category: analine-glyoxylate aminotransferase]]
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[[Category: Zhou CZ]]
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[[Category: glycolate pathway]]
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[[Category: Van Tilbeurgh H]]
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[[Category: pyridoxal-5-phosphate]]
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[[Category: sad]]
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[[Category: transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:03:17 2008''
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Current revision

Yeast alanine:glyoxylate aminotransferase YFL030w

PDB ID 2bkw

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