2y3v

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==N-TERMINAL HEAD DOMAIN OF DANIO RERIO SAS-6==
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<StructureSection load='2y3v' size='340' side='right' caption='[[2y3v]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
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==N-terminal head domain of Danio rerio SAS-6==
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<StructureSection load='2y3v' size='340' side='right'caption='[[2y3v]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2y3v]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y3V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y3V FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2y3v]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y3V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y3V FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2y3w|2y3w]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.92&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y3v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y3v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y3v RCSB], [http://www.ebi.ac.uk/pdbsum/2y3v PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y3v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y3v OCA], [https://pdbe.org/2y3v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y3v RCSB], [https://www.ebi.ac.uk/pdbsum/2y3v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y3v ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SAS6_DANRE SAS6_DANRE]] Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells.<ref>PMID:21273447</ref>
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[https://www.uniprot.org/uniprot/SAS6_DANRE SAS6_DANRE] Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells.<ref>PMID:21273447</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Centrioles are cylindrical, nine-fold symmetrical structures with peripheral triplet microtubules strictly required to template cilia and flagella. The highly conserved protein SAS-6 constitutes the center of the cartwheel assembly that scaffolds centrioles early in their biogenesis. We determined the x-ray structure of the N-terminal domain of SAS-6 from zebrafish and show that recombinant SAS-6 self-associates in vitro into assemblies that resemble cartwheel centers. Point mutations are consistent with the notion that centriole formation in vivo depends on the interactions that define the self-assemblies observed here. Thus, these interactions are likely essential to the structural organization of cartwheel centers.
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Structures of SAS-6 Suggest Its Organization in Centrioles.,van Breugel M, Hirono M, Andreeva A, Yanagisawa HA, Yamaguchi S, Nakazawa Y, Morgner N, Petrovich M, Ebong IO, Robinson CV, Johnson CM, Veprintsev D, Zuber B Science. 2011 Jan 27. PMID:21273447<ref>PMID:21273447</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Danio rerio]]
[[Category: Danio rerio]]
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[[Category: Breugel, M Van]]
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[[Category: Large Structures]]
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[[Category: Basal body]]
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[[Category: Van Breugel M]]
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[[Category: Cartwheel]]
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[[Category: Cartwheel hub]]
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[[Category: Centriole]]
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[[Category: Cytoskeleton]]
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[[Category: Structural protein]]
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Current revision

N-terminal head domain of Danio rerio SAS-6

PDB ID 2y3v

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