4kz3

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==Crystal structure of AmpC beta-lactamase in complex with fragment 44 (5-chloro-3-sulfamoylthiophene-2-carboxylic acid)==
==Crystal structure of AmpC beta-lactamase in complex with fragment 44 (5-chloro-3-sulfamoylthiophene-2-carboxylic acid)==
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<StructureSection load='4kz3' size='340' side='right' caption='[[4kz3]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
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<StructureSection load='4kz3' size='340' side='right'caption='[[4kz3]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4kz3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KZ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KZ3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4kz3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KZ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KZ3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1U1:5-CHLORO-3-SULFAMOYLTHIOPHENE-2-CARBOXYLIC+ACID'>1U1</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.67&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kz4|4kz4]], [[4kz5|4kz5]], [[4kz6|4kz6]], [[4kz7|4kz7]], [[4kz8|4kz8]], [[4kz9|4kz9]], [[4kza|4kza]], [[4kzb|4kzb]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1U1:5-CHLORO-3-SULFAMOYLTHIOPHENE-2-CARBOXYLIC+ACID'>1U1</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kz3 OCA], [https://pdbe.org/4kz3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kz3 RCSB], [https://www.ebi.ac.uk/pdbsum/4kz3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kz3 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kz3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kz3 RCSB], [http://www.ebi.ac.uk/pdbsum/4kz3 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AMPC_ECOLI AMPC_ECOLI]] This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.
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[https://www.uniprot.org/uniprot/AMPC_ECOLI AMPC_ECOLI] This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4kz3" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Beta-lactamase]]
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[[Category: Escherichia coli K-12]]
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[[Category: Barelier, S]]
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[[Category: Large Structures]]
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[[Category: Eidam, O]]
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[[Category: Barelier S]]
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[[Category: Fish, I]]
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[[Category: Eidam O]]
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[[Category: Shoichet, B K]]
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[[Category: Fish I]]
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[[Category: Ampc beta-lactamase]]
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[[Category: Shoichet BK]]
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[[Category: Cephalosporinase]]
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[[Category: Class c]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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Current revision

Crystal structure of AmpC beta-lactamase in complex with fragment 44 (5-chloro-3-sulfamoylthiophene-2-carboxylic acid)

PDB ID 4kz3

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